Helix BioPharma Corp. Completes Fourth Dosing Cohort and Initiates Enrollment of the Next Cohort in U.S. Combination Treatment Study of Its Lung Cancer Drug Candidate L-DOS47

On July 25, 2018 Helix BioPharma Corp. (TSX, FSE: HBP) ("Helix" or the "Company"), an immuno-oncology company developing innovative drug candidates for the prevention and treatment of cancer, reported that the Safety Review Committee ("SRC") reviewed safety data from the fourth dosing cohort of the Company’s LDOS001 study and recommended that Helix begin enrollment of patients into the fifth dosing cohort (Press release, Helix BioPharma, JUL 25, 2018, http://www.helixbiopharma.com/helix-biopharma-corp-completes-fourth-dosing-cohort-initiates-enrollment-next-cohort-u-s-combination-treatment-study-lung-cancer-drug-candidate-l-dos47/ [SID1234528420]). LDOS001 is a dose escalation study of L-DOS47 with pemetrexed and carboplatin in recurrent or metastatic non-squamous non-small cell lung cancer. Patients enrolled in th fifth dosing cohort will receive the next L-DOS47 dose level which is 6.0 micrograms of L-DOS47 per kilogram of patient body weight.The combination of L-DOS47 with pemetrexed and carboplatin continues to be safe and well tolerated.

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The two patients in the previous two cohorts dosed with 1.5 and 3.0 micrograms of L-DOS47 experienced a stable and a partial tumor response at their first imaging assessment respectively. This brings the total number of treated patients experiencing a partial response to five (5) out of eleven (11). The range of tumor size reduction is from 33% to 91%. The program expects to recruit seven (7) more patients in the next three (3) cohorts, provided no dose limiting toxicities are observed.

"We are very encouraged that a significant group of treated patients are experiencing a reduction in their tumor growth," said Heman Chao, CEO Helix’s Chief Executive Officer. "We look forward to receiving more data and continuing to advance the L-DOS47 development program