On February 9, 2021 Herantis Pharma Plc ("Herantis"), an innovative clinical stage biotech company pioneering new disease modifying and regenerative biologic and gene therapies, reported that they have entered into a Biologics Proof of Concept Agreement with Nanoform Finland Plc, an innovative nanoparticle medicine enabling company (Press release, Herantis Pharma, FEB 9, 2021, https://news.cision.com/herantis-pharma-oyj/r/herantis-pharma-and-nanoform-enter-into-agreement-for-proof-of-concept-collaboration,c3282448 [SID1234577510]). The collaboration provides for formulation Proof of Concept studies (PoCs) to combine Herantis’ intranasally administered CDNF therapy for Parkinson’s disease, with Nanoform nanoparticle technology.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Following completion of the Phase I study with CDNF in Parkinson’s Disease (PD) in August 2020, the Company announced that moving forward it would focus on additional administration routes not requiring invasive surgery, such as intranasal administration. This strategy is intended to target earlier stage patients, accelerate development timelines, and expedite potential partnering transactions. In parallel to the Company’s ongoing intranasal program for CDNF, the Nanoform project will also separately assess possible enhancement of intranasal drug delivery to the brain of CDNF therapy for Parkinson’s Disease using Nanoform’s proprietary biological nanoparticle technology. This collaboration will compliment Herantis’ current development program on additional administration routes for CDNF. Under the agreement, Nanoform will undertake up to two proof of concept studies with Herantis’ CDNF molecules.
"CDNF is now one of a few clinical stage assets in development with the potential for disease modification of Parkinson’s Disease. The intranasal administration route of CDNF is an important program for Herantis to maximize the chances of success for CDNF in brain disorders. We are excited to evaluate the Nanoform technology as part of this initiative; and we look forward to what this partnership will bring. It is our hope that this collaboration will shine a light on new possibilities to improve the lives of patients with Parkinson’s and other related diseases," said Dr. Craig Cook, CEO, Herantis Pharma.
"We are delighted to finalize this collaborative Agreement with Herantis and initiate our partnership together. Brain delivery for biologicals and small molecules is an immensely challenging route of administration and we firmly believe nanoparticles have a significant role to play in enhancing and hopefully enabling this. We are excited with the prospect of exploring how our nanoparticles can potentially enable drug delivery opportunities and solve challenges in this space," said Christian Jones, Chief Commercial Officer of Nanoform.