On November 4, 2020 Humanigen, Inc., (Nasdaq:HGEN) ("Humanigen"), a clinical stage biopharmaceutical company focused on preventing and treating an immune hyper-response called ‘cytokine storm’ by neutralizing granulocyte-macrophage colony-stimulating factor (GM-CSF) with its lead therapeutic candidate lenzilumab, the company’s proprietary Humaneered anti-human-GM-CSF immunotherapy, reported the acceptance of an abstract describing the ongoing ZUMA-19 study for presentation at the 62nd American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting & Exposition, to be held virtually from December 5-8, 2020 (Press release, Humanigen, NOV 4, 2020, View Source [SID1234569881]).

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"The rationale for GM-CSF neutralization with CAR-T cell therapy is appealing and well-understood and we look forward to discussing this ongoing trial at ASH (Free ASH Whitepaper) in collaboration with our research partners," said Cameron Durrant, MD, MBA, chief executive officer of Humanigen.

ZUMA-19 is a joint Humanigen/Kite, a Gilead Company, clinical study that is being conducted as part of a clinical collaboration in the US. The ongoing ZUMA-19 Phase 1b/2 multicenter study is evaluating lenzilumab in adults with relapsed/refractory large B-cell lymphoma (R/R LBCL) who are receiving CAR-T cell therapy with axicabtagene ciloleucel.

The abstract, titled "ZUMA-19: A Phase 1/2 Multicenter Study of Lenzilumab Use with Axicabtagene Ciloleucel (Axi Cel) in Patients (Pts) With Relapsed or Refractory Large B Cell Lymphoma (R/R LBCL)," will be presented as a Trials-in-Progress poster (Abstract #2103) on Sunday, December 6 at 10:00 a.m. ET.