On September 19, 2022 Hummingbird Bioscience, a data-driven precision biotherapeutics company discovering and developing transformative biologic medicines for hard-to-treat diseases, reported that Jerome Boyd-Kirkup, Ph.D., Hummingbird Bioscience’s Chief Scientific Officer, will present at the 2nd Annual VISTA Symposium on September 23, 2022 (Press release, Hummingbird Bioscience, SEP 19, 2022, View Source [SID1234619654]).
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"VISTA is a promising therapeutic target we believe has not been adequately drugged to date due to its complex biology," said Dr. Boyd-Kirkup. "I am excited to join the symposium to discuss the potential of anti-VISTA therapies alongside leading researchers and clinicians in immunology. Our differentiated, clinical-stage, anti-VISTA antibody HMBD-002 has potential as an important new therapy that may address VISTA-mediated immunosuppression across a broad range of tumors."
The symposium will focus on VISTA’s function and applicability in cancer immunology, as well as the latest research and development in programs targeting VISTA.
Hummingbird Bioscience published preclinical data demonstrating the therapeutic potential of HMBD-002 in VISTA-expressing cancers in February 2022. A Phase 1 clinical trial NCT05082610 evaluating HMBD-002 is open and enrolling.
About HMBD-002
HMBD-002 is an investigational IgG4 anti-VISTA antagonist antibody produced by our RAD platform to target the region where VISTA interacts with binding partners that have been shown to play an important role in modulating T cell activity, potentially unlocking the immune system to attack cancer cells. Due to complex biology, VISTA has not been adequately drugged to date. We believe HMBD-002 is the first Fc-independent anti-VISTA antibody designed to bind a computationally predicted functional epitope distinct from the epitopes of other known anti-VISTA antibodies in development. In the Company’s preclinical studies, HMBD-002 demonstrated potent anti-tumor activity both as monotherapy and in combination with pembrolizumab, in multiple syngeneic and humanized mouse models of cancers. HMBD-002 is being developed for various VISTA-expressing cancers, both as a monotherapy and in combination with pembrolizumab. The development of HMBD-002 is supported in part by a grant from the Cancer Prevention and Research Institute of Texas (CPRIT, DP190027).