On March 23, 2022 Ichnos Sciences Inc., a global biotechnology company developing novel multispecific antibodies for the treatment of cancer using the proprietary BEAT platform1, reported that preclinical data for ISB 1442, a first-in-class 2+1 biparatopic bispecific antibody that targets both CD38 and CD47, will be presented at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, to be held in New Orleans from April 8-13, 2022 (Press release, Ichnos Sciences, MAR 23, 2022, View Source [SID1234610703]). ISB 1442 is being investigated as a treatment for relapsed/refractory multiple myeloma, T-cell acute lymphoblastic leukemia and acute myeloid leukemia.

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"The data being presented at AACR (Free AACR Whitepaper) highlight the potential for ISB 1442, our first-in-class biparatopic CD38 x CD47 bispecific antibody, in multiple myeloma," said Stefano Sammicheli, Ph.D., Director of Innate Cell Engagers, at Ichnos Sciences. "This compound has shown higher potency and greater inhibition of tumor growth relative to daratumumab in both in vitro and in vivo models, suggesting that ISB 1442 may overcome common mechanisms of resistance to other CD38 targeted therapies, which is coupled with low potential for on-target off-tumor effects seen with other CD47 directed treatments."

"We are excited to have the opportunity to present at AACR (Free AACR Whitepaper), and to share ISB 1442 data that support our plan to move this drug into a Phase 1 study in the middle of this year," said Cyril Konto, M.D., President and Chief Executive Officer of Ichnos Sciences. "Advancing ISB 1442 is particularly important to Ichnos because it is built using BEAT 2.0, which is among the most advanced antibody engineering platforms and the basis of our discovery efforts for novel multispecifics to treat hematologic malignancies and solid tumors."

Ichnos Sciences continues to advance its pipeline of agents based on the proprietary BEAT technology platform. Using this platform, Ichnos Sciences is exploring the full design space for treating cancer and engineering multispecific antibodies capable of simultaneously engaging tumor and immune cells.

Details for the poster presentation are shared below:

Session PO.IM02.10 – Therapeutic Antibodies 2
April 12, 2022, 9:00 AM – 12:30 PM

2903 / 18 – ISB 1442, a first-in-class CD38 and CD47 bispecific antibody innate cell modulator for the treatment of CD38+ malignancies

Posters will be available on-demand on the AACR (Free AACR Whitepaper) website at www.aacr.org beginning at the start of the poster session and the abstract is available to view here.