On November 6, 2024 Immunomic Therapeutics, Inc., ("ITI"), a privately-held clinical-stage biotechnology company pioneering the study of LAMP-mediated nucleic acid-based immunotherapy reported that it will present at SITC (Free SITC Whitepaper) 39th Annual Meeting 2024 at the George R. Brown Convention Center in Houston, TX on November 8-10, 2024 (Press release, Immunomic Therapeutics, NOV 6, 2024, View Source [SID1234647869]). Associate Director, Vaccine Discovery, Wei Shen, Ph.D., will present a poster entitled, "A UNITE-based self-amplifying RNA vaccine advances anti-tumor immunity in a murine triple-negative breast cancer model" on Friday, November 8th & Saturday, November 9th, 2024.
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Poster Presentation details are as follows:
Abstract: 223
Title: A UNITE-based self-amplifying RNA vaccine advances anti-tumor immunity in a murine triple-negative breast cancer model
Date and Time: Friday, November 8, 2024 ǀ 9:00 a.m.- 7:00 p.m. CST & Saturday, November 9, 2024 ǀ 9:00 a.m.- 8:30 p.m. CST
Poster Number: 223
Where: George R. Brown Convention Center, Level 1, Exhibit Halls AB
Speaker: Dr. Wei Shen, Ph.D.
About UNITE
ITI’s investigational UNITE platform, UNiversal Intracellular Targeted Expression, leverages the ability to engineer chimeric proteins, directing antigen presenting cells to present antigens to the immune system through a targeted pathway and driving a robust immune response. UNITE vaccines are distinct in that they combine two components: nucleic acid constructs that encode a specific antigen and an endogenous Lysosomal Associated Membrane Protein (LAMP-1) sequence. The UNITE platform harnesses LAMP-1 as a means of presenting the vaccine target to the immune system, resulting in antibody production, inflammatory cytokine release, and establishing critical immunological memory, something that other vaccine approaches commonly lack. This approach could put UNITE technology at the crossroads of immunotherapies in multiple indications, including cancer, human allergy, animal health, and infectious disease. Preclinical data is currently being developed to explore whether LAMP-1 nucleic acid constructs may amplify and activate the immune response in highly immunogenic tumor types and used to create immune responses in tumor types that otherwise do not provoke an immune response.