On March 9, 2022 IMV Inc. (Nasdaq: IMV; TSX: IMV), a clinical-stage company developing a portfolio of immune-educating therapies based on its novel DPX platform to treat solid and hematologic cancers, reported that the Company will showcase its DPX delivery technology in two presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, taking place April 8-13, 2022, in New Orleans, Louisiana (Press release, IMV, MAR 9, 2022, View Source [SID1234609763]).
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"Data to be presented suggest that our DPX delivery platform instructs an innate immune response involving NK cells in addition to the previously recognized role for T and B cells," said Jeremy Graff, Ph.D., Chief Scientific Officer at IMV Inc. "This finding supports our clinical strategy to combine our lead compound with other therapies that have a complementary mechanism of action to increase tumor destruction while preserving a favorable safety profile." Translational research using both clinical samples from the DeCidE ovarian cancer trial and tissues from pre-clinical models will be presented showing for the first time that natural killer (NK) cells play a distinct role in promoting anti-tumor responses to the company’s lead DPX-peptide immunotherapeutic, Maveropepimut-S.
In an oral presentation in a late-breaking session about immunotherapeutic combinations, Dr. Olivier Rixe will present safety and efficacy data from the IMV Phase 2 basket study evaluating MVP-S in combination with pembrolizumab and cyclophosphamide in patients with advanced, metastatic bladder cancer. Presentations Details Dr. Rixe and members from the IMV team will attend the conference and both presentations will be available on the conference platform and on the IMV website under the Scientific Publications & Posters section.
NK cells are involved in promoting anti-tumor responses to DPX-peptide immunotherapy
Presenter: Moamen Bydoun, Ph.D., Senior Research Scientist at IMV
Poster Number: 623
Date/Time: Sunday Apr. 10, 2022, 1:30 p.m. – 5:00 p.m. CST
Safety, preliminary efficacy and pharmacodynamic (PD) analysis of maveropepimut-S, intermittent low-dose cyclophosphamide and pembrolizumab in patients with advanced, metastatic bladder cancer
Presenter: Olivier Rixe, M.D., Ph.D., Quantum Santa Fe, New Mexico
Session Title: Immunotherapy Combination Strategies in Clinical Trials
Presentation Number: CT035
Session Date and Time: Tuesday Apr. 12, 2022, 2:30 p.m. – 4:30 p.m. CST