On October 4, 2016 IncellDx, Inc., a single cell, precision medicine company, reported that the international peer-reviewed medical journal Cancer Immunology, Immunotherapy has published a manuscript entitled: "Quantification of PD-L1 and PD-1 expression on tumor and immune cells in non-small cell lung cancer (NSCLC) using non-enzymatic tissue dissociation and flow cytometry (Press release, IncellDx, OCT 4, 2016, View Source [SID:SID1234515589])." Dr. Bruce Patterson, MD, Founder and CEO explained that this is a novel, single cell approach to quantifying the expression of PD-L1 and PD-1 expression on tumor and immune cells in non-small cell lung cancer (NSCLC) tumor samples. The methodology has been validated on both fine needle aspiration (FNA) and tumor biopsies. The samples are non-enzymatically homogenized into single cell suspensions using IncellDx’s IncellPREP kit yielding a single-cell sample before a formalin-fixed paraffin embedded (FFPE) block is made.

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As Dr. Patterson explained, "We believe this objective quantitation of PD-L1 expression in tumor and immune cells in NSCLC will allow for better prediction of patient response to the new PD-1 immunotherapies within a work flow that is suited well for primary indications where the initial diagnosis may be made using several approaches to sampling the tumor. Further, the assay and sample preparation are automated allowing for same day turn around."

The PD-L1 and PD-1 assay is the first release of IncellDx, Inc.’s newest family of single cell, multi-parametric molecular products called OncoTect iO for immuno-oncology in a multitude of tissue types. The paper is now available online at View Source