On October 16, 2023 Inspirna, Inc., a clinical stage biopharmaceutical company developing first-in-class cancer therapeutics, reported that data from the ongoing Phase 1b/2 study of ompenaclid (RGX-202) in combination with FOLFIRI and bevacizumab (BEV) in RAS-mutated (RASm) advanced or metastatic colorectal cancer (CRC) will be presented at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress 2023 being held October 20-24, 2023 in Madrid, Spain (Press release, Inspirna, OCT 16, 2023, View Source [SID1234636002]).
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Ompenaclid is a first-in-class oral inhibitor of the creatine transport channel SLC6A8, a novel target that is enriched under hypoxic conditions and provides tumor cells with an additional energy source. Ompenaclid triggers tumor regressions in CRC patients by inducing apoptosis of tumor cells. The Phase 1b/2 study of ompenaclid in combination with FOLFIRI/BEV in second-line (2L) advanced or metastatic CRC patients has completed enrollment, with an ongoing follow up period. The primary endpoint of the study is to determine maximum tolerated dose (MTD), objective response rate (ORR), and treatment-emergent adverse events (TEAEs). In the dose escalation stage of the study, two dose levels of ompenaclid with FOLFIRI/BEV have been evaluated in patients with CRC with disease progression after a first-line oxaliplatin-containing regimen.
Poster Presentation Details
Title: Phase 1b/2 study of ompenaclid (RGX-202-01), a first-in-class oral inhibitor of the creatine transporter SLC6A8, in combination with FOLFIRI and bevacizumab (BEV) in RAS mutated (RASm) second-line (2L) advanced/metastatic colorectal cancer (mCRC)
Presenter: Andrew Hendifar, M.D., Assistant Professor of Medicine at Cedars-Sinai Medical Center and Study Principal Investigator
Onsite Poster Display Date: Sunday, October 22, 2023 at 9:00 AM CEST
Presentation Number: 646P
Conference Call and Webcast
Inspirna will host a virtual KOL panel on Sunday, October 22, 2023 at 6:30 PM CEST / 12:30 PM ET with Andrew Hendifar, M.D., to discuss these clinical data. The event may be accessed by registering at View Source A webcast of the event will be available on the "Events and Presentations" page of the Company’s website at View Source The archived webcast will be available on the Company’s website within 24 hours after the event.