On October 13, 2023 InterVenn Biosciences, a life sciences company pioneering glycoproteomics, reported the publication of their discovery work in Advanced Adenoma (AA) and Colorectal Cancer (CRC) early disease detection in the flagship journal of the American Gastroenterological Association, Gastroenterology (Press release, InterVenn Biosciences, OCT 13, 2023, View Source [SID1234635962]). This groundbreaking research in early detection of CRC represents an advancement in early diagnosis through serum glycoproteome profiling. InterVenn’s GlycoVision platform leverages advanced liquid chromatography-mass spectrometry (LC-MS) combined with artificial intelligence (AI) and neural networks (NN) to interrogate a new layer of biology, enabling novel insights and discoveries.
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The results published in Gastroenterology establish the groundwork for a blood-based CRC screening modality using artificial intelligence to reveal the earliest stages of colorectal cancer. The proprietary LC-MS and AI/NN platform, GlycoVision, has been developed to accelerate data analysis of biological information that has not previously been practical or efficient.
The research involved a comprehensive case-control analysis using well-annotated blood samples from 279 cases (CRC and advanced adenomas) and 296 control samples. InterVenn’s sophisticated LC-MS-based glycoproteomic quantification workflow was employed, resulting in the development of a novel multivariable classifier model using six key biomarkers, which, when applied to a test set, achieved an Area under the Receiver Operating Characteristic curve (AuROC) of 0.96, signifying notable sensitivity and specificity in detecting both CRC and advanced adenoma. The classifier exhibited a sensitivity of 90.9% for advanced adenoma without high grade dysplasia, 85.7% for Advanced Adenoma with High Grade Dysplasia and 89.8% for all stages of CRC, including 91.2% for early-stage (stage 1 and 2) CRC, and 89.4% for late-stage (stage 3 and 4) CRC, along with high specificity of 89% for normal findings.
"InterVenn’s novel AI-powered glycoprotein-based strategy is among the most differentiated and compelling value propositions in the diagnostic industry," said Josh Stahl, InterVenn’s recently appointed CEO. "The resulting performance of the GlycoVision platform has the potential to aid patients, providers, and payers in the early diagnosis of colorectal cancer."
"This collaborative study, conducted in partnership with some of the world’s foremost experts in colorectal cancer, represents a pivotal milestone in advancing the development of an innovative blood-based CRC screening test," stated Daniel Hommes, gastroenterologist and Chief Medical Officer.
Details on the Publication:
Desai K, Gupta S, May FP, Xu G, Shaukat A, Hommes DW, NICE-AA/CRC- Consortium, Early detection of advanced adenomas and colorectal carcinoma by serum glycoproteome profiling., Gastroenterology (2023), doi: View Source