On November 15, 2023 Ionetix Corporation reported the signing of a supply agreement for the therapeutic radioisotope actinium-225 (Ac-225) with Bayer (Press release, Bayer, NOV 15, 2023, View Source [SID1234637719]). Under the terms of the agreement, Ionetix will provide Bayer with high-purity, non-carrier added (n.c.a.) Ac-225.
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Ac-225 is an alpha-emitter and when attached to a tumor seeking molecule, can deliver therapeutic doses of radiation directly to tumors, destroying the cancer cells while sparing the surrounding healthy tissue. Precision targeting of cancer using targeted radionuclide therapies (TRT) is a promising new cancer treatment approach. However, the global availability of Ac-225 is limited and currently there are very few production resources. Therefore, there is an immediate need for new sources of Ac-225 supply that can scale effectively to support the development of these new cancer treatments.
"We recognized the emerging demand and made the early investment to develop a commercial-scale production solution for Ac-225 using our expertise in cyclotron accelerator and target technology," said David Eve, VP of Medical Affairs for Ionetix Corporation. Located in Lansing, Michigan, Ionetix has established a new isotope production facility that is dedicated to manufacturing alpha-emitters. The first cyclotron was commissioned at the facility earlier this year and installation of a second cyclotron is planned for 2024. Both cyclotrons will be used to produce alpha-emitters, providing both onsite redundancy and increased capacity to scale output. Distribution of GMP grade, n.c.a. Ac-225 will begin in early 2024.