On April 25, 2023 J INTS BIO reported the poster presentation of its novel, orally administered TKI ‘JIN-A04’ targeting NSCLC with HER2 exon 20 insertion mutation at the annual meeting of the American Association of Cancer Research 2023, which was held in Orlando, USA from April 14 to 19 (Press release, J INTS BIO, APR 25, 2023, View Source;presentation-of-preclinical-study-results-of-jin-a04-an-oral-target-therapy-for-her2-exon-insertion-mutation-nsclc-301807638.html [SID1234630499]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Approximately 2-4% of NSCLC patients have mutations in HER2, and 90% of these mutations are exon 20 insertions. Unfortunately, treatment options for patients with HER2 exon 20 insertion mutations are limited, and there is currently no approved oral targeted therapy.

The data presented showed that "JIN-A04" has potent efficacy against HER2 Exon20 insertion mutant NSCLC cell lines while showing no activity in normal cell lines in an in-vitro study, and in-vivo mouse models using HER2 Exon20 insertion mutation cell lines showed strong inhibitory activity with significant tumor regression.

J INTS BIO said, "JIN-A04, an oral TKI for NSCLC, is expected to provide a powerful treatment option for NSCLC patients with HER2 exon 20 insertion mutations," and expressed strong aspirations that "it could be the most promising Best-in-Class TKI in the treatment of NSCLC."