On August 13, 2020 KAHR Medical reported the company’s participation in Oppenheimer’s Private Life Sciences Company Call Series taking place virtually August 17-19, 2020 (Press release, KAHR Medical, AUG 13, 2020, View Source [SID1234563617]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Yaron Pereg, Ph.D., Chief Executive Officer of KAHR Medical, has been invited to present an overview of the Company’s Fusion Protein Technology and its lead, clinical stage, anti-CD47 candidate developed for the treatment of solid tumors.
Details regarding the Company’s presentation are as follows:
Event: Oppenheimer’s Private Life Sciences Company Call Series
Date: Monday, August 17, 2020
Time: 12:15 PM ET – 12:50 PM ET
About DSP107
DSP107 targets CD47-overexpressing tumors, simultaneously blocking macrophage inhibitory signals and delivering an immune costimulatory signal to tumor antigen-specific, activated T-cells. CD47 is overexpressed on many cancer cells and binds SIRPα on immune phagocytic cells to produce a "don’t eat me" signal. DSP107 binds CD47 on cancer cells, blocking interaction with SIRPα and thus, blocking the "don’t eat me signal". Simultaneously, DSP107 binds 41BB on T-cells, stimulating their activation. These activities lead to targeted immune activation through both macrophage and T-cell mediated tumor destruction. Recently, the U.S. Food and Drug Administration has cleared an investigational new drug (IND) application for DSP107. Under this IND, the Company intends to initiate a Phase I/II clinical trial to evaluate the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of DSP107 as a monotherapy and in combination with Roche’s PD-L1-blocking checkpoint inhibitor (CPI) atezolizumab (Tecentriq) in patients with advanced solid tumors. The study will be conducted at multiple centers in the United States and site activation activities are currently underway. The study will be conducted under a clinical collaboration with Roche.