On March 23, 2021 Lantern Pharma Inc. (NASDAQ: LTRN), a clinical stage biopharmaceutical company using its proprietary RADR artificial intelligence ("A.I.") platform to transform oncology drug discovery and development, reported that it will present new data on LP-184, a next-generation, targeted small molecule in the acylfulvene drug class, showcasing its potency across various 2D and 3D models of prostate cancer, at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting, taking place from April 10-15, 2021 (Press release, Lantern Pharma, MAR 23, 2021, View Source;utm_medium=rss&utm_campaign=new-data-supporting-lp-184-advancement [SID1234577018]).
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Lantern’s poster will highlight the spectrum of DNA damage repair defects, occurring in 25-30% of metastatic castration resistant prostate cancer (mCRPC) patients, against which LP-184 shows nanomolar potency. "In vitro studies of LP-184 continue to show potentially best in class efficacy in metastatic prostate cancer with a novel mechanism of action," stated Panna Sharma, CEO and President of Lantern Pharma. "Our ongoing work of LP-184 in metastatic prostate cancer in collaboration with Georgetown University has shown effectiveness in tumor models with mutations in DNA damage repair pathway components including in genes involved in Homologous Recombination and Transcription Coupled-Nucleotide Excision Repair. We look forward to sharing this new data at AACR (Free AACR Whitepaper) and developing this compound towards the clinic and for the benefit of prostate cancer patients."
Details of the abstract are as follows:
Title: LP184, a novel alkylating agent, is efficacious in prostate cancer models with DNA damage repair defects
Session Category: Experimental and Molecular Therapeutics
Session Title: Novel Antitumor Agents
Permanent Abstract Number: 1249
The full text of the abstract is now available on the AACR (Free AACR Whitepaper) Annual Meeting 2021 website.
The accompanying poster will be available to view to registered participants during the conference via the AACR (Free AACR Whitepaper) e-poster website on April 10, 2021, and published on the company website after the conference.