On October 25, 2023 Bio-Techne Corporation (NASDAQ: TECH) reported that Lunaphore, a Bio-Techne brand, will have its technologies featured in several presentations by prominent research centers at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 38th Annual Meeting, taking place in San Diego, November 1-5, 2023 (Press release, BioNTech, OCT 25, 2023, View Source [SID1234636345]). The recent studies will demonstrate the unmatched spatial biology capabilities of the company’s universal, end-to-end COMET product suite, addressing complex biological questions from various research areas. COMET is the only fully automated, high-throughput, hyperplex platform ensuring scalability and reproducibility without the need to conjugate primary antibodies, making panel design much more flexible and faster than any other hyperplex solution.

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Lunaphore’s sponsored symposia will provide novel insights into the optimization of innovative anti-cancer therapy approaches for head and neck squamous cell carcinoma (HNSCC). Researchers from the collaborative research project between the Earle A. Chiles Research Institute a division of Providence Cancer Institute, and Lunaphore will present the results of a hyperplex-based characterization of the tumor microenvironment (TME) in response to combined immunotherapy and stereotactic ablative radiation therapy (iSABR) neoadjuvant treatment of HNSCC, facilitated by the COMET platform. The presentation will discuss strategies for rapid hyperplex sequential immunofluorescence (seqIF) panel development and optimization, as well as methodologies for high-throughput data analytics. The novel seqIF method allows an unprecedented analysis of the immune compartment and potentially increases the clinical success of such therapies.

Additionally, poster presentations will highlight how research institutes use their off-the-shelf antibodies on COMET to map immune and tumoral cells in lymphomas and various cancer tissues with the seqIF approach. Furthermore, a poster of industry partnership will demonstrate proof-of-concept COMET workflow for same-slide, fully automated multiomics analysis of the TME.

Lunaphore’s scientists will be available at booth #530 to provide live demonstrations of the COMET system and access to raw staining images of various cancer types.

Sponsored symposia details

Using hyperplex immunofluorescence to characterize the immune response to iSABR in head and neck cancer

Location: room 15AB

Date & Time: November 3, 2023 | 12:15 – 1:15 PM EST

Speakers:

Dr. Brian Piening, Earle A. Chiles Research Institute a division of Providence Cancer Institute, USA
Dr. Rom Leidner, Earle A. Chiles Research Institute a division of Providence Cancer Institute, USA
Dr. Marco Cassano, Lunaphore – a Bio-Techne brand, Switzerland
The symposia will take place during the lunch break. Lunaphore will provide lunch for the attendees.

Poster presentation details

Development and optimization of a broad hyperplex immunofluorescence assay for tumor immune microenvironment characterization
Poster number: 65
Date & Time: November 3, 2023 | 12:15 – 1:15 PM | 5:10 – 6:40 PM EST
Presenter: Racheli Ben-Shimol, B.Sc., Earle A. Chiles Research Institute a division of Providence Cancer Institute, USA

Automated hyperplex staining and imaging system on various cancer tissues using off-the-shelf antibodies
Poster number: 222D
Date & Time: November 4, 2023 | 11:55 AM-1:25 PM | 7:00 – 8:30 PM
Presenter: Ms. Li Yen Chong, Institute of Molecular Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore

Immune landscape of adenoid cystic carcinoma using multiplex immunofluorescence and digital pathology
Poster number: 102
Date & Time: November 4, 2023 | 11:55 AM-1:25 PM
Presenter: Dr. Annie Li, Massachusetts General Hospital and Harvard Medical School, USA

Profiling cytokeratins in the tumor microenvironment using multiplex immunofluorescence
Poster number: 1475
Date & Time: November 3, 2023 | 12:00 – 1:30 PM | 5:10 – 6:40 PM
Presenter: Danielle Fails, Spatial Biology Manager, Fortis Life Sciences, USA

Adding space to TiME by sequential immunofluorescence: a new dimension for the spatial biomarkers painting in a clinical cohort of lymphoma case
Poster number: 107
Date & Time: November 3, 2023 | 1:30 PM | 5:10 – 6:40 PM
Presenter: Dr. Pedro Machado Almeida, Lunaphore – a Bio-Techne brand, Switzerland
Research conducted in collaboration with École Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research.

Integration of RNA in situ hybridization and sequential immunofluorescence for same-slide fully automated multi-omics analysis of the tumor microenvironment
Poster number: 71
Date & Time: November 3, 2023 | 2:00 – 1:30 PM | 5:10 – 6:40 PM
Presenter: Dr. Alice Comberlato, Lunaphore – a Bio-Techne brand, Switzerland
Research conducted in collaboration with ACD – a Bio-Techne brand, USA.

The posters are available during the conference opening times of the given day. Presenters will hold the reception at the given time.

Learn more about the event and book a meeting with Lunaphore here.