LOAd703 is an adenovirus serotype 5/35 armed with TMZ-CD40L and 4-1BBL (Company Web Page, Lokon Pharma, MAY 13, 2016, View Source [SID:1234512342]). TMZ-CD40L and 4-1BBL are two potent stimulators of anti-tumor immunity by their capacity to activate dendritic cells and M1 macrophages to produce IL12, TNFa, IFNg and IL21, as well as to expand both T cells and NK cells.

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