On August 12, 2021 Lynk Pharmaceuticals Co., Ltd. (hereinafter referred to as ‘Lynk Pharmaceuticals’), an innovative drug development company, reported that it has administered its triple-kinase inhibitor LNK01002 to the first patient in a phase I clinical trial (Press release, Lynk Pharmaceuticals, AUG 12, 2021, View Source [SID1234586540]). This is a multi-center, open label phase I clinical study to evaluate the safety, tolerance and pharmacokinetics of LNK01002 in patients with primary myelofibrosis (PMF) and secondary myelofibrosis (PV/ET-MF) induced by polycythemia vera or primary thrombocytosis.
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LNK01002 is an innovative triple-kinase inhibitor independently developed by Lynk Pharmaceuticals. LNK01002 simultaneously targets three kinase drivers of PMF and PV/ET-MF with the potential to effectively treat patients who are not responsive, or have developed resistance to, conventional therapies and thus addresses a global unmet clinical need with a potential first in class therapy.
"In preclinical studies, we have demonstrated better anticancer activity and safety in comparison with other mono- or dual-kinase inhibitors", said Dr. Sherry Weigand, Chief Medical Officer of Lynk Pharmaceuticals, "Rapid clinical studies of LNK01002 in patients will accelerate evaluating its therapeutic value more quickly and thoroughly. As a novel therapy, we hope that LNK01002 will benefit patients in need as soon as possible."
"This first-in-patient study of LNK01002 is an important milestone, as it formally marks the start of its clinical stage of studies." said Zhao-Kui (ZK) Wan, Founder and CEO of Lynk, "we look forward to seeing the clinical outcomes, and hope LNK01002 will bring a better and additional treatment for the patients worldwide."