MaaT Pharma to Provide Data Update for Lead Microbiome Biotherapeutic in Oral Presentation at 62nd American Society of Hematology (ASH) Annual Meeting

On November 26, 2020 MaaT Pharma reported that updated results from its compassionate use program for lead microbiome therapeutic MaaT013 will be reported in an oral presentation at the virtual 62nd American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting held from December 5 -8, 2020 (Press release, MaaT Pharma, NOV 26, 2020, View Source [SID1234571795]). The results include data from 29 patients with gastrointestinal, acute Graft-versus-Host-Disease (aGvHD) who were resistant to multiple lines of treatments and were treated with the full-ecosystem microbiome restoration biotherapeutic. MaaT Pharma provided the product to hospitals under an expanded access treatment program in France called Autorisation Temporaire d’Utilisation Nominative (ATUn). MaaT013 is an enema formulation of a microbiome biotherapeutic characterized by a consistent high diversity and richness of microbial species, derived from pooled donations from healthy individuals. The data will be presented by Dr. Florent Malard, MD, PhD, Associate Professor of Hematology at Saint-Antoine Hospital and Sorbonne University, who participated in the treatment program.

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Oral Presentation details:

Title: Successful and Safe Treatment of Intestinal Graft-Versus-Host Disease (GvHD) with Pooled-Donor Full Ecosystem Microbiota Biotherapeutic: Results from a 29 Patient-Cohort of a Compassionate Use/Expanded Access Treatment Program

Abstract No: 422

Session Name: 722. Clinical Allogeneic Transplantation: Acute and Chronic GvHD, Immune Reconstitution: Pathobiology and Predictive Biomarkers

Date/Time: Sunday, December 6, 2020 / 1:00 PM EDT

MaaT Pharma will announce the results through a press release on Monday, December 7, 2020.

The company is also investigating its lead biotherapeutic, MaaT013, in the HERACLES trial, a multi-center, single-arm, open-label Phase II clinical study in steroid-refractory, predominantly gastrointestinal aGvHD patients (NCT03359980).