On May 25, 2017 MabVax Therapeutics Holdings, Inc. (Nasdaq: MBVX), a clinical-stage biotechnology company with a fully human antibody discovery platform focused on the rapid translation into clinical development of products to address unmet medical needs in the treatment of cancer, reported that results from the Phase I clinical trial of MabVax’s therapeutic antibody MVT-5873, being evaluated in advanced pancreatic cancer and other CA19-9 positive cancers, will be presented in a poster presentation at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting to be held in Chicago, IL, June 2 – 6, 2017 (Press release, MabVax, MAY 25, 2017, View Source [SID1234519293]). Schedule your 30 min Free 1stOncology Demo! MabVax Therapeutics Logo (PRNewsfoto/MabVax Therapeutics Holdings, I)
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As part of the presentation, MabVax will discuss the results of the Company’s dose-escalation and safety trial, conducted over the last year in 32 patients with advanced pancreatic and colon cancer. Additionally, single agent MVT-5873 safety profile, efficacy, and reductions in serum CA19-9 levels over time will be presented.
Title of Presentation: Single agent HuMab-5B1 (MVT-5873), a monoclonal antibody targeting sLea, in patients with pancreatic cancer and other CA19-9 positive malignancies.
Abstract Number: 4110
Location: Gastrointestinal (Non-colorectal) Cancer Session
Session Date: Saturday, June 3rd
Time: 8:00 AM to 11:30 AM (CDT)
The Phase I therapeutic trial is an open-label, dose-escalation study evaluating the safety, tolerability and pharmacokinetics of MVT-5873. The first group of patients enrolled assess safety and determined the recommended Phase II dose of the antibody. The second patient group will establish the safety and dose of the antibody when administered with a standard-of-care chemotherapy. Dr. Eileen O’Reilly, associate Director of the David M. Rubenstein Center for Pancreatic Cancer Research, attending physician, member at Memorial Sloan Kettering Cancer Center and Professor of Medicine at Weill Cornell Medical College is the lead investigator in the MVT-5873 Phase I clinical trial.