On March 25, 2021 MAIA Biotechnology, Inc., a biotechnology company focused on the development of targeted, first-in-class oncology drugs, reported that company management is presenting at the following virtual investor conferences (Press release, MAIA Biotechnology, MAR 25, 2021, View Source [SID1234577173]):
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Keiretsu Midwest Angel Forum: March 23-25, 2021
Keiretsu Forum is a global investment community of accredited private equity angel investors, venture capitalists and corporate/institutional investors.
MedInvest Spring 2021 Oncology Investor Conference: March 29 – April 2, 2021
MedInvest Spring is sponsored by the National Foundation for Cancer Research and is a well-known event for cancer related companies seeking investment.
During these conferences, MAIA will present an overview of the company including several recent and upcoming milestones that will advance the company and its pipeline. In February 2021, MAIA entered into a clinical supply agreement with Regeneron Pharmaceuticals, Inc. to evaluate its lead program, THIO (aka 6-thio-dG), followed by the PD-1 inhibitor Libtayo (cemiplimab), in a Phase 1/2 clinical trial in second-line or later advanced non-small cell lung cancer (NSCLC) patients who have progressed following treatment with standard-of-care regimen that includes a checkpoint inhibitor. Libtayo was approved by the US FDA to treat first-line advanced NSCLC in February 2021.
This clinical trial will evaluate the safety and efficacy of four dose levels of THIO, the only telomere-by-telomerase targeting agent in development for the treatment of cancer, followed by Libtayo. The lead-in portion of the study will assess the safety and immunogenic effects of each of the THIO doses and overall response rate (ORR) as the basis for potentially expanding individual patient cohorts and evaluation in other cancer types. The Phase 1/2 clinical trial is expected to begin enrolling patients in 2021.
The presentations made by MAIA at Keiretsu and MedInvest will be available to registered conference attendees.
About THIO
THIO (aka 6-thio-dG, 6-thio-2’-deoxyguanosine) is a first-in-class small molecule that is the only telomere-by-telomerase targeting agent currently in development. THIO selectively kills cancer cells by modifying telomeric DNA structure and function utilizing telomerase. Telomerase is present in >85% of human cancers and contributes significantly to the proliferation and reproductive immortality of cancer cells. THIO’s activity was shown to be cancer-specific in tumor types with active telomerase. THIO is recognized by telomerase and incorporated into telomeres selectively in cancer cells. Once incorporated, it compromises the telomere structure and function, leading to ‘uncapping’ of the chromosome ends and thus resulting in rapid tumor cell death. Low doses of THIO, followed by anti-PD-L1 or anti-PD1 therapy, completely eliminated advanced tumors in preclinical models and produced cancer cell specific immune memory, where the immune system continued to be active against the cancer cells after extended periods of time, with no additional treatment. These results demonstrate how the THIO-produced telomere stress increases innate sensing and adaptive anti-tumor immunity, which provides a strong rationale for sequentially combining telomere-targeted therapy with immunotherapy. THIO is investigational and has not been approved for any use by regulatory authorities.