On March 22, 2023 Marengo Therapeutics, Inc., a company pioneering novel immuno-therapeutics targeting the T cell receptor (TCR) Vβ repertoire to fight cancer and other diseases, reported that the company will present a late-breaking abstract at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, held April 14-19 in Orlando, Florida (Press release, Marengo Therapeutics, MAR 22, 2023, View Source [SID1234629191]). Building on recent scientific insights into Marengo’s lead asset, STAR0602, which selectively activates and expands Vβ6 T cells, Marengo will present new data revealing the broad utility of targeting different T cell subsets expressing distinct Vβ TCRs utilizing its STAR (Selective T Cell Activation Repertoire) platform to remodel the adaptive immune response to refractory solid tumors.
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"As we continue to explore the hidden reactivities of the germline TCR repertoire using our proprietary libraries of anti-TCR antibodies, we are uncovering exciting immunology with potential broad therapeutic application across a range of cancers and other immune-related diseases," said Andrew Bayliffe, Ph.D., Chief Scientific Officer of Marengo Therapeutics. "Importantly, we also find that Marengo’s anti-TCR antibody constructs transform Vβ T cells towards a novel phenotype that drives potent anti-tumor activity in vivo via a mechanism of action that is both unique and distinct from anti-PD1 immunotherapy."
Details of the presentation are as follows:
Title: A novel class of T cell-activators targeting germline encoded TCR β chains promotes antitumor activity in PD1-refractory models through expansion of a clonally diverse effector memory T cell subset
Authors: Jacques Moisan, Madan Katragadda, Jonathan Hsu, Jessica Lowry, Wei Huang, Jian Tang, Roya Servattalab, Gurkan Guntas, Raj Chopra, Zhen Su, and Andrew Bayliffe
Session Title: Late-Breaking Research: Immunology 3
Session Date and Time: Wednesday Apr 19, 2023, 9:00 AM – 12:30 PM
Poster Section: 3
Poster Number: 6
Abstract Presentation Number: LB338