On April 11, 2023 Medigene AG (Medigene, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, reported that it will present a poster at the European Society for Blood and Marrow Transplantation (EBMT) 2023 annual meeting being held on April 23-26, 2023 in Paris (Press release, MediGene, APR 11, 2023, View Source [SID1234629958]).
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The data to be presented show the full results from the CD-TCR-001 dose escalation study with MDG1011, a T cell receptor engineered T cell (TCR-T) therapy directed against the tumor antigen PRAME (PReferentially expressed Antigen in MElanoma) with HLA-A*02:01, in heavily pre-treated patients suffering from different hematological malignancies. MDG1011 was well-tolerated, with efficacy most evident at the highest dose level tested. Data also showed that MDG1011 cells were still detectable after several months while PRAME levels decreased and remained low.
The abstract for this clinical study has been published online View Source and the accompanying presentation in the form of an ePoster will be available online on April 23, 2023.
ePoster details
AS-EBMT-2023-00737:
First-in-Human Study of MDG1011, a TCR-T Cell Therapy directed against HLA-A*02:01-Restricted PRAME, for High-Risk Myeloid and Lymphoid Neoplasms (CD-TCR-001)
Simone Thomas, Martin Wermke, Vladan Vucinic, Eva Wagner-Drouet, Andreas Mackensen, Robert Zeiser, Gesine Bug, Michael Schmitt, Petra Prinz, Dolores Schendel, Kai Pinkernell, René Goedkoop