On October 13, 2025 Merus N.V. (Nasdaq: MRUS) (Merus, the Company, we, or our), an oncology company developing innovative, full-length multispecific antibodies and antibody drug conjugates (Biclonics, Triclonics and ADClonics), reported the acceptance of two abstracts on petosemtamab, a Biclonics targeting EGFR and LGR5, for presentation at the AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper), being held in Boston, Massachusetts on October 22-26, 2025 (Press release, Merus, OCT 13, 2025, View Source [SID1234656596]).
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Initial interim data from the phase 2 trial evaluating petosemtamab in combination with standard chemotherapy in 1L and 2L metastatic colorectal cancer (mCRC), and as monotherapy in heavily pretreated (3L+) mCRC will be presented in a plenary session by Dr. Moh’d Khushman M.D., Washington University School of Medicine, St. Louis, MO. Merus will also present a poster regarding the preclinical evaluation of petosemtamab on cancer stem cells.
Presentations:
Title: Petosemtamab (MCLA-158) monotherapy or with chemotherapy in metastatic colorectal cancer: Preliminary antitumor activity and safety data from a phase 2 trial
Session Title: Plenary Session 4: Clinical Trials Plenary Session
Date and Time: Friday, October 24 10:00-11:40 a.m. ET
The same data will also be available in a poster:
Session Title: Poster Session B
Session Date and Time: Friday, October 24, 12:30-4:00 p.m. ET
Poster presentation:
Title: Preclinical evaluation of petosemtamab, an epidermal growth factor receptor (EGFR) and leucine-rich repeat-containing G protein-coupled receptor (LGR5) bispecific antibody, on cancer stem cells
Session Title: Poster Session B
Session Date and Time: Friday, October 24, 12:30-4:00 p.m. ET
The abstracts will be available in the conference app on Wednesday, October 22, 2025 at 12:00 p.m. ET. The full presentations are planned to be available on the Merus website at the start of each session.
About Petosemtamab
Petosemtamab, or MCLA-158, is a Biclonics low-fucose human full-length IgG1 antibody targeting the epidermal growth factor receptor (EGFR) and the leucine-rich repeat containing G-protein-coupled receptor 5 (LGR5). Petosemtamab is designed to exhibit three independent mechanisms of action including inhibition of EGFR-dependent signaling, LGR5 binding leading to EGFR internalization and degradation in cancer cells, and enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) activity.