On March 10, 2021 Merus N.V. (Nasdaq: MRUS) ("Merus", "the Company", "we", or "our"), a clinical-stage oncology company developing innovative, full-length multispecific antibodies (Biclonics and Triclonics), reported that Merus will present preclinical data from our zenocutuzumab and MCLA-129 programs in three poster presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) 2021 Annual Meeting being held virtually for two weeks, April 10-15, 2021 and May 17-21, 2021 (Press release, Merus, MAR 10, 2021, View Source [SID1234576518]).
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E-Poster Presentation:
Title: The HER2×HER3 bi-specific antibody zenocutuzumab is effective at blocking growth of tumors driven by NRG1 gene fusions
Abstract #: 956
Session Category: Experimental and Molecular Therapeutics
Session Title: Biological Therapeutic Agents
Title: Zenocutuzumab: An antibody that can overcome HER3 mediated HRG signaling in tumor cells by docking on HER2
Abstract Number: 957
Session Category: Experimental and Molecular Therapeutics
Session Title: Biological Therapeutic Agents
Title: The bispecific antibody MCLA-129 impairs NSCLC tumor growth by targeting EGFR and c-MET, inhibiting ligand-induced signaling and promoting ADCC and ADCP
Abstract Number: 952
Session Category: Experimental and Molecular Therapeutics
Session Title: Biological Therapeutic Agents
Abstracts are available on the AACR (Free AACR Whitepaper) annual meeting website.
The AACR (Free AACR Whitepaper) e-poster website will be launched on Saturday April 10, 2021. All e-posters will be available on this website from Saturday, April 10 to Monday, June 21, 2021. The posters will also be available on the Merus website as of Saturday, April 10, 2021.
About Zeno
Zeno is an antibody-dependent cell-mediated cytotoxicity (ADCC)-enhanced Biclonics that utilizes the Merus Dock & Block mechanism to inhibit the neuregulin/HER3 tumor-signaling pathway in solid tumors with NRG1 gene fusions (NRG1+). Through its unique mechanism of binding to HER2 and potently blocking the interaction of HER3 with its ligand NRG1 or NRG1-fusion proteins, Zeno has the potential to be particularly effective against NRG1+ cancers. In preclinical studies, Zeno also potently inhibits HER2/HER3 heterodimer formation and tumor growth in models harboring NRG1 fusions.
Learn more about Zeno Dock & Block at View Source
About MCLA-129
MCLA-129 is an ADCC-enhanced Biclonics that is designed to inhibit the EGFR and c-MET signaling pathways in solid tumors. Preclinical data has shown that MCLA-129 reverses resistance to tyrosine kinase resistant non-small cell lung cancer (NSCLC) cell lines resulting in tumor growth inhibition in xenograft models of NSCLC. MCLA-129 is designed to have two complementary mechanisms of action: blocking growth and survival pathways to stop tumor expansion and recruitment and enhancement of immune effector cells to eliminate the tumor.