On March 10, 2021 Mirati Therapeutics, Inc. (NASDAQ: MRTX), a late-stage targeted oncology company, reported it will present initial preclinical data on the Company’s synthetic lethal PRMT5 inhibitor during a late-breaking minisymposium at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting taking place April 10-15, 2021 (Press release, Mirati, MAR 10, 2021, View Source [SID1234576437]).
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"At Mirati, we are applying leading-edge drug discovery strategies, such as synthetic lethality, to translate this exciting research approach into meaningful, targeted therapeutic options for patients with cancer," said James Christensen, Ph.D., executive vice president and chief scientific officer, Mirati Therapeutics, Inc. "We look forward to presenting early preclinical data at AACR (Free AACR Whitepaper) from our internally-discovered, potentially first-in-class, synthetic lethal PRMT5 inhibitor, as an example of how Mirati is progressing the science of novel targets."
Mirati is developing a novel synthetic lethal PRMT5 inhibitor targeting the methylthioadenosine phosphorylase (MTAP)-deleted patient population. Deletions of the MTAP gene locus are commonly observed in pancreatic, lung, and bladder cancers, among others, and are linked to poor patient outcomes. PRMT5 is an enzyme critical to the survival of normal and tumor cells and is partially inhibited by methylthioadenosine (MTA) which accumulates in MTAP-deleted cancers. Mirati’s differentiated approach selectively targets the PRMT5/MTA complex in MTAP-deleted cancer cells while sparing normal cells and represents a precision medicine strategy.
Presentation Details
Title: Fragment based discovery of MRTX9768, a synthetic lethal-based inhibitor designed to bind the PRMT5/MTA complex and selectively target MTAP/CDKN2A-deleted tumors
Author: Matthew Marx, Ph.D., senior vice president, drug discovery, Mirati Therapeutics, Inc.
Abstract #: LB003
Late-Breaking Minisymposium 1
Saturday, April 10, 2021, 1:30 p.m. – 3:30 p.m.