On October 19, 2022 Monopar Therapeutics Inc. (Nasdaq: MNPR), a clinical-stage biopharmaceutical company focused on developing proprietary therapeutics designed to extend life or improve the quality of life for cancer patients, reported that the abstract on its drug candidate MNPR-202 has been selected for a poster presentation at the 64th ASH (Free ASH Whitepaper) Annual Meeting & Exposition (ASH 2022) (Press release, Monopar Therapeutics, OCT 19, 2022, View Source [SID1234622182]). ASH (Free ASH Whitepaper) 2022, being held in New Orleans, is the premier event in malignant and non-malignant hematology. This poster will be the first release of data from Monopar’s ongoing collaboration with Dr. Anand Jeyasekharan of the Cancer Science Institute of Singapore, National University of Singapore Hospital.
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Dr. Jeyasekharan is exploring how MNPR-202 affects DNA damage response and immune system pathways in cancer cells, resulting in cell death. The aim is to identify cancer indications where MNPR-202 could have significant potential as a monotherapy and/or in combination with immunotherapy. MNPR-202 was designed to retain the same potentially non-cardiotoxic backbone as Monopar’s clinical-stage doxorubicin analog camsirubicin, but is modified at other positions which may enable it to work in certain cancers that are resistant to camsirubicin and doxorubicin.
"We have been thrilled with the progress of the collaboration," said Chandler Robinson, MD, Monopar’s Chief Executive Officer. "Dr. Jeyasekharan is a leading expert on how the immune system recognizes cancer cells upon DNA-damaging chemotherapy, and his insights and preclinical experiments have yielded promising and helpful data. We are excited for the opportunity to share the findings at ASH (Free ASH Whitepaper) 2022."