On October 28, 2020 The Multiple Myeloma Research Foundation (MMRF) and Indapta Therapeutics reported a partnership to support the advancement of the company’s universal G-NK cell therapy into clinical trials for the treatment of patients with multiple myeloma (Press release, Indapta Therapeutics, OCT 28, 2020, View Source [SID1234569250]). Indapta Therapeutics, Inc., is a biotechnology company focused on developing and commercializing a proprietary, off-the-shelf, allogeneic FcRγ-deficient natural killer (G-NK) cell therapy for the treatment of multiple cancers. The collaboration is supported with an investment in Indapta by the MMRF’s venture philanthropy arm, the Myeloma Investment Fund (MIF).
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"Our investment in Indapta’s G-NK cell therapy is consistent with our strategy to fund the development of first-in-class, potentially transformative treatments," said Paul Giusti, President and Chief Executive Officer of the MMRF. "Indapta’s off-the-shelf cell therapy uses a promising new class of NK cells, which could provide a significant benefit for patients."
About Indapta’s G-NK Cell Therapy
Indapta Therapeutics is developing a universal, allogeneic G-NK cell therapy designed to substantially improve the cytotoxicity of monoclonal antibody therapy in multiple cancers. G-NK cells are a specific and potent subset of NK (natural killer) cells with specialized anti-tumor activity resulting from an epigenetic change, rather than engineering. Indapta has further enhanced G-NK cells via specific G-NK cell subset selection and its proprietary manufacturing process which, when combined, produce a G-NK cell therapy that demonstrates higher efficacy, persistence, and enhanced cryopreservation than multiple mAb therapies alone or mAb therapies combined with conventional NK cells.
When a monoclonal antibody binds to the tumor target and to Indapta’s G-NK cell therapy product, it initiates the release of dramatically more cancer killing compounds than conventional NK cells, allowing for increased efficacy and potentially less frequent dosing. Indapta’s off-the-shelf G-NK cell therapy is further differentiated from other NK cell therapies in that it is a cell banked product with low variability. In vivo studies have demonstrated the safety of Indapta’s G-NK cell therapy.
"This collaboration with the MMRF and MIF will be invaluable in helping us advance the clinical development of our universal, allogeneic G-NK cell therapy," said Guy DiPierro, Founder, and Chief Executive Officer of Indapta Therapeutics. "We look forward to tapping into MMRF’s deep myeloma expertise and other critical resources, including genomic datasets. The Foundation’s insights into patient recruitment and study networks will help us reach multiple myeloma patients for our own clinical trials."