On September 13, 2022 Nascent Biotech, Inc. (OTCQB:NBIO) ("Nascent Biotech", "Nascent", or the "Company"), a clinical-stage biotechnology Company pioneering the development of monoclonal antibodies targeting various cancer types, reported the completion of the Fourth Cohort in dosing patients in the Company’s Phase I trial to evaluate Pritumumab ("PTB") as a treatment for Brain Cancer, including Primary and metastatic Brain Tumors (Press release, Nascent Biotech, SEP 13, 2022, View Source [SID1234619502]).
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After reviewing data gathered from the four completed cohorts, this milestone will allow the trial to advance to a fifth and final cohort. Patient enrollment continues for Phase I and interested parties may review trial requirements at www.clinicaltrials.gov under the search term ‘Pritumumab’.
Following completion of dosing of the Fifth Cohort, the Phase I trial will be complete, and the Company will prepare data for submission to the FDA in preparation for Phase 2 clinical research.
"Having completed four cohorts, we are enthusiastic about moving to our fifth and likely final cohort in the Phase I trial," noted Nascent CEO, Sean Carrick. "The data received so far has been very encouraging. We will continue to perform PK studies on the fourth and fifth cohorts to support an upcoming data submission to the FDA."
PTB is a natural human antibody that binds to Cell surface Vimentin (also referred to as ectodomain vimentin), a protein expressed on the surface of epithelial cancers. PTB is used as a targeted immunotherapy and seek out only cancer cells without damaging healthy cells.