On November 20, 2019 Navrogen Inc. and Lonza Pharma & Biotech reported that they have entered a licensing agreement for the production of Navrogen’s biotherapeutics using Lonza’s GS Xceed Expression System (Press release, Navrogen, NOV 20, 2019, View Source [SID1234551520]).
Navrogen recently announced funding to develop biotherapeutics targeting Humoral Immuno-Oncology (HIO) factors to reverse their inhibitory activity against the pharmacologic effects of antibody-based therapies. Navrogen’s biological drugs involve novel protein and antibody-based configurations. Lonza’s GS Xceed toolbox includes GS PiggyBac, a unique and proven transposon-based technology suited for complex protein expression and bioprocessing that preferentially targets stable regions of the genome associated with highly expressed genes. This system will play a key role in advancing Navrogen’s novel therapeutic interventions from the laboratory bench to patient’s bedside.
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"We are pursuing novel targets, called HIO factors, produced by tumor cells that dampen the effect of a number of antibody-based therapeutics. To overcome the immuno-suppressive effects of these factors we developed a pipeline of uniquely engineered, biological-based compositions that may require optimized systems to facilitate their production at large scale for clinical trials", commented Dr. Luigi Grasso, Ph.D., co-founder and Chief Scientific Officer of Navrogen.
Dr. Nicholas Nicolaides, Ph.D., Navrogen’s co-founder and Chief Executive Officer said "Our collaboration with Lonza and their expertise will undoubtedly enable us to advance our pipeline of first-in-class products forward to meet our strategic initiatives and timelines. This partnership is one of many that we have formed with top-tiered vendors who have proven track records in supporting the development of biological-based therapies to support clinical trials and commercialization."
"Developing new technologies to enable production of increasingly complex and hard-to-express biological drugs is a priority for Lonza. Navrogen’s use of our GS PiggyBac system aligns the economics of bringing these first-in-class therapeutics to patients with current market needs", commented Dr Sarah Holland, Head of licensing, Lonza Pharma & Biotech.