On October 20, 2021 NeoTX Therapeutics (NeoTX), a clinical-stage immuno-oncology company, reported that the first patient has been enrolled in the company’s phase 2a clinical trial of naptumomab estafenatox (NAP), its lead Tumor Targeted Superantigen (TTS) candidate, in combination with docetaxel in patients with advanced non-small cell lung cancer (NSCLC) (Press release, NeoTX, OCT 20, 2021, View Source [SID1234591620]).

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"Dosing of the first patient in this phase 2 trial represents a crucial step forward for the clinical advancement of NAP" said Asher Nathan, Ph.D., chief executive officer of Neo TX. "This trial is based on promising phase 1 data. NSCLC is one of the deadliest cancers, and we are looking forward to evaluating NAP in this setting".

The phase 2a, open label trial in the US, will assess NAP in combination with docetaxel in patients who had been previously treated with checkpoint inhibitors and have advanced or metastatic NSCLC. The primary endpoint is objective response rate as measured by RECIST 1.1 criteria. The trial will also evaluate safety, duration of response, progression free survival, overall survival, pharmacokinetics, and pharmacodynamics. For more information about the trial, visit View Source