On October 21, 2022 NeuBase Therapeutics, Inc. (Nasdaq: NBSE) ("NeuBase" or the "Company"), a biotechnology platform company Drugging the Genome to address disease at the base level using a new class of precision genetic medicines, reported a research agreement with a Top 10 Global Healthcare company ("Healthcare Company") (based on 2021 revenues) (Press release, NeuBase Therapeutics, OCT 21, 2022, View Source [SID1234622271]). For this research, the Healthcare Company will evaluate NeuBase’s PATrOL technology for three monogenic genetic diseases.

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NeuBase’s PATrOL platform is a PNA-based technology designed to address disease at the root of causality to help patients with rare and common diseases by editing, upregulating, or downregulating gene function. PATrOL gene editing is differentiated in that it does not require bacterial enzymes (e.g., CRISPR-Cas9), which potentially increases fidelity and reduces immunogenicity to provide a safer solution to patients for in vivo gene editing.

"Our PATrOL technology enables us to create a series of peptide nucleic acids (PNAs) designed to target a genetic mutation and recruit the cell’s own high fidelity nucleic acid repair machinery to resolve the mutation," stated Dietrich A. Stephan, Ph.D., Chief Executive Officer of NeuBase. "We look forward to working with our Healthcare Company partner to explore our novel gene editing technology for several genetic diseases."

Under the terms of the agreement, NeuBase and the Healthcare Company will collaborate on the evaluation of drug candidates for three undisclosed indications. The Healthcare Company will have the exclusive opportunity, subject to certain terms and conditions, to license and develop the drug candidates created under this research evaluation agreement.