On March 14, 2017 Cellectar Biosciences, Inc. (Nasdaq: CLRB) (the "company"), an oncology-focused, clinical stage biotechnology company, reported the Japanese Patent Office has granted a composition of matter patent for the company’s optical imaging phospholipid drug conjugates (PDCs), CLR 1501 and CLR 1502 (Press release, Cellectar Biosciences, MAR 14, 2017, View Source [SID1234518136]). Schedule your 30 min Free 1stOncology Demo!
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The recently issued patent, JP6073961, describes CLR 1501 and CLR 1502 for use in intraoperative tumor imaging both in vitro and in vivo. The patent allows intellectual property protection in Japan through May 11, 2030. Both compounds utilize the company’s PDC delivery platform for tumor targeting optimization.
"This patent represents another demonstration of both the unique properties and varied utility of our PDC platform," said Jim Caruso, president and CEO of Cellectar. "While our focus continues to be the development of the PDC platform for therapeutic uses, including our lead product candidate CLR 131 in hematologic malignancies, the additional global patent protection provides us with unique opportunities for partnerships to further explore the clinical utility of our technology and enhance the value of the platform."
About Phospholipid Drug Conjugates (PDCs)
Cellectar’s product candidates are built upon its patented cancer cell-targeting delivery and retention platform of optimized phospholipid ether-drug conjugates (PDCs). The company deliberately designed its phospholipid ether (PLE) carrier platform to be coupled with a variety of payloads to facilitate both therapeutic and diagnostic applications. The basis for selective tumor targeting of our PDC compounds lies in the differences between the plasma membranes of cancer cells compared to those of normal cells. Cancer cell membranes are highly enriched in lipid rafts, which are glycolipoprotein microdomains of the plasma membrane of cells that contain high concentrations of cholesterol and sphingolipids, and serve to organize cell surface and intracellular signaling molecules. PDCs have been tested in more than 80 different xenograft models of cancer.