On November 9, 2021 Australian clinical-stage drug development company Noxopharm (ASX:NOX) reported its DARRT-2 Phase 2 clinical trial has commenced with patient enrollment in the U.S (Press release, Noxopharm, NOV 9, 2021, View Source [SID1234594938]).

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DARRT (Direct and Abscopal Response to Radiotherapy) is an experimental immunotherapy cancer treatment based on the concept of Veyonda combining with a well-tolerated, low dosage of external beam radiotherapy to trigger an immune response — known as an abscopal response — which may lead to the resolution of tumors.

DARRT treatment has the potential to revolutionize cancer treatment by achieving cancer reduction without many of the unwanted side effects, cost limitations, and logistical challenges associated with other immunotherapies.

Since low dose radiotherapy is a common form of cancer therapy, the therapeutic and commercial opportunities of adding Veyonda to transform symptomatic relief into a meaningful tumor response are substantial. Noxopharm is confident of securing the value of this opportunity by patents, starting with the allowance of claims by the U.S. Patent Office.

The inaugural sites are the Beverly Hills Cancer Center and the MD Anderson Cancer Center, with remaining sites in North America, Europe, and Australia.

Noxopharm Chief Medical Officer, Dr. Gisela Mautner, said, "The participation of institutions with prestigious radiation and medical oncologists is testament to the potential of the DARRT-treatment."