On August 19, 2019 On Target Laboratories, Inc., a privately held biotechnology company that is developing tumor-targeted fluorescent imaging agents to improve cancer surgery, reported that it has completed its Phase 2, multi-center, open-label clinical trial for OTL38 in the detection of lung cancer nodules in lung cancer patients during surgery (Press release, On Target Laboratories, AUG 19, 2019, https://www.prnewswire.com/news-releases/on-target-completes-otl38-phase-2-clinical-trial-in-lung-cancer-300903646.html [SID1234538872]). Top-line data from the trial are expected to be reported in the first half of 2020.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
The Phase 2 study assessed the efficacy, safety and tolerability of OTL38 used intraoperatively in patients with suspected lung cancer. OTL38 is an imaging agent consisting of a folate receptor targeting ligand linked to a highly fluorescent near-infrared dye, which specifically targets folate receptors overexpressed in multiple cancers, including non-small cell lung cancers. For more information on the trial refer to www.clinicaltrials.gov, using the NCT identifier NCT02872701.
"Completing the OTL38 Phase 2 trial in lung cancer is a major milestone for On Target Laboratories," said Chris Barys, newly appointed CEO of On Target Laboratories, who recently succeeded outgoing CEO Martin Low. "The completion of this study propels us one step closer to FDA approval and commercialization which will bring a much-needed advancement in imaging for patients undergoing image-guided surgery for lung cancer."
About OTL38
OTL38, which is being evaluated in clinical trials in ovarian cancer and lung cancer, is a novel compound consisting of a folate receptor targeting ligand, linked to a near-infrared dye which specifically targets folate receptors overexpressed in multiple cancer types.