On November 14, 2022 OncoNano Medicine, Inc. reported the presentations of positive preclinical data on the company’s ON-BOARD pH-activatable delivery platform at the 37th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) in Boston, Massachusetts (Press release, OncoNano Medicine, NOV 14, 2022, View Source [SID1234624015]).
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The data presented at SITC (Free SITC Whitepaper) 2022 demonstrated the capability of the ON-BOARD platform for effective encapsulation and improvement of the therapeutic index of a variety of therapeutic payloads, including bispecific T cell engagers (TCE) and a therapeutic cytokine – IL-2-Fc, using relevant animal models.
The ON-BOARD platform is designed to protect oncology intervention payloads systemically and release them in the acidic tumor microenvironment, minimizing systemic exposure and toxicity. OncoNano’s lead clinical candidate, pegsitacianine, currently in Phase 2 clinical trials, is formulated with ON-BOARD, and the clinical data has validated its pH-activated tumor specificity.
In the two separate presentations, a variety of TCEs including solitomab, runimotamab and several TCEs with undisclosed targets as well as a human IL-2 fused with IgG Fc were encapsulated using the ON- BOARD platform. The data demonstrated that:
ON-BOARD successfully encapsulated TCEs across a range of different targets and structural configurations without any protein engineering involved
ON-BOARD-encapsulated TCEs demonstrated rapid release and high pH specificity as well as pH- activated cytotoxicity against various cancer cell lines in vitro
ON-BOARD encapsulation of an undisclosed TCE significantly improved its tolerability in vivo compared to the unencapsulated molecule and inhibited the growth of a poorly immunogenic "cold" tumor model with in-tumor payload activation confirmed by PD markers
ON-BOARD-encapsulated IL-2-Fc showed robust anti-tumor efficacy in both the "hot" MC38 and the "cold" B16F10 tumors and greatly suppressed systemic toxicity compared to unencapsulated IL-2-Fc
"We were excited to share the positive data on the encapsulation of a variety of bispecific T cell engagers and a therapeutic cytokine and the significant improvement of therapeutic index without complicated protein engineering," said Tian Zhao, PhD, Vice President of Research and Development at OncoNano. "We look forward to developing this technology for clinical translation with these types of payload molecules in the near future."