On November 11, 2022 OncoResponse, a clinical-stage biotech company advancing immunotherapies derived from the immune systems of Elite Responders, reported preclinical data on immuno-oncology candidates OR2805 and OR502 presented at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 37th Annual Meeting (Press release, OncoResponse, NOV 11, 2022, View Source [SID1234623853]).
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OR2805 is a fully human monoclonal antibody identified from an Elite Responder using OncoResponse’s proprietary B-cell discovery platform. OR502 is a novel humanized antibody to leukocyte immunoglobulin-like receptor-B2 (LILRB2, ILT4) protein.
"Our data presented at SITC (Free SITC Whitepaper) highlight the ability of OR2805 and OR502 to modulate inhibitory macrophages in the tumor microenvironment and induce anti-tumor immune activity. In preclinical models, OR502 restores innate and adaptive immune responses by modulating immunosuppressive myeloid cells and can reverse unresponsiveness to anti-PD-1 treatment," said Kamal Puri, PhD, Chief Scientific Officer of OncoResponse. "These initial, promising data support continued development of these candidates."
"We are pleased to present preclinical scientific data on our pipeline of macrophage-modulating antibodies that support advancement to clinical studies: OR2805 now in Phase 1, and OR502 slated for IND in 2023," said Clifford Stocks, Chief Executive Office of OncoResponse.
Presentation highlights include:
Abstract Number: 39
Interrogating Elite Responder humoral responses to identify novel targets and therapeutic antibodies for the treatment of cancer
OR2805 demonstrates specific binding to immunosuppressive myeloid cells.
M2c macrophages treated with OR2805 promote T-cell activation and proliferation.
OR2805 induces anti-tumor activity in humanized mouse models.
OR2805 amplifies anti-PD-1 activity in M2c/T cell coculture assays demonstrating potential as a single agent or in combination with checkpoint inhibitors.
Interrogation of humoral responses in Elite Responders is an attractive strategy for discovery of novel targets and therapeutic antibodies for the treatment of cancer.
Abstract Number: 498
Preclinical characterization of OR502, an anti-LILRB2 antibody that rescues innate and adaptive immune responses from LILRB2 mediated immune suppression
OR502 demonstrates specific binding to LILRB2 and blocks interaction of LILRB2 with its all-relevant ligands.
OR502 modulates the immunosuppressive function of TAMs and enhances adaptive anti-tumor responses in M2c/CD8+ T cell coculture assays.
OR502 boosts LPS-induced IFN-γ secretion by peripheral blood mononuclear cells.
The data demonstrate robust anti-tumor activity in humanized mouse models.
Our results support further development of OR502 for cancer immunotherapy.
Accessing Posters
The OncoResponse posters presented at SITC (Free SITC Whitepaper) are accessible on the Publications & Presentations page of the OncoResponse website.