On November 4, 2021 Orion Biotechnology Canada Ltd., a clinical stage company unlocking the therapeutic potential of G Protein-Coupled Receptors (GPCRs) with a novel drug modality, proven discovery platform and best-in-class molecules, reported that it is receiving advisory services and conditional funding from the National Research Council of Canada Industrial Research Assistance Program (NRC IRAP) (Press release, Orion Biotechnology, NOV 4, 2021, View Source [SID1234595541]). The funding will support the development of Orion’s lead compound, OB-002, a GPCR analog of CCL5 with best-in-class potency and broad applicability across a range of serious diseases including cancer and neuroinflammation. Working in collaboration with NRC’s Human Health Therapeutics Research Centre, the objectives of the project will be to further expand the translational research of OB-002, including an assessment of the molecules’ ability to cross the blood brain barrier (BBB).
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"We are very pleased to receive advisory services and this funding from NRC IRAP," said Mark Groper, President and CEO of Orion Biotechnology. "Their support will help accelerate development of OB-002 as a potentially important therapy for the treatment of serious illnesses".
"GPCRs are implicated in a wide range of human physiological processes and we are interested in expanding our knowledge of OB-002’s pharmacological profile and mechanism of action," commented Ian McGowan, Orion’s Chief Medical Officer. "This project, supported by NRC IRAP and our collaborators, will prove important as we continue to progress OB-002 into the clinic"