On March 15, 2023 OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnemo: OSE) (Paris:OSE) reported it will be presenting five posters at the 2023 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting (Press release, OSE Immunotherapeutics, MAR 15, 2023, View Source [SID1234628856]). AACR (Free AACR Whitepaper) will be held in person in Orlando (Florida) on April 14-19.

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Four communications will feature the latest research on pre-IND programs for the pioneering Myeloid and BiCKI platforms, namely presentations on CLEC-1 (new myeloid immune checkpoint) and BiCKI-IL7 (new bifunctional therapy targeting PD-1 and IL-7), and OSE-127 (anti-IL-7 receptor antagonist) hematology program. A fifth communication will feature biomarker analyses on BI 765063 (anti-SIRPα monoclonal antibody on CD47/SIRPα pathway) from the ongoing Phase 1 clinical trial in advanced solid tumors.

Nicolas Poirier, Chief Executive Officer of OSE Immunotherapeutics, comments: "We are very pleased to have several poster presentations at the prestigious AACR (Free AACR Whitepaper) annual meeting. This selection by the international scientific community underlines the recognition and the interest in the quality of our R&D engines with preclinical and clinical innovative research programs. It further highlights our long-term commitment to fight against debilitating cancer and chronic diseases through the development of first-in-class innovative immunotherapies."

Poster presentation details:

Poster CLEC#1*

Title: ""CLEC-1 inhibitory myeloid checkpoint blockade enhances antitumor responses and tumor phagocytosis by macrophages""
Session Category: Immunology
Session Title: Immune Checkpoints
Session Date and Time: April 19, 2023 – 9:00 AM – 12:30 PM
Location: Section 23
Poster Board Number: 2

Poster CLEC#2*

Title: "TRIM21 is a novel endogenous partner of the inhibitory myeloid checkpoint CLEC-1 involved in tumor antigen cross-presentation"
Session Category: Immunology
Session Title: Immune Checkpoints
Session Date and Time: April 19, 2023 – 9:00 AM – 12:30 PM
Location: Poster Section 23
Poster Board Number: 9

Poster BiCKI-IL-7

Title: "Anti-PD-1/IL-7v bispecific antibody promotes TCF1+ stem like CD8 T cells expansion and long-lasting in vivo efficacy"
Session Category: Immunology
Session Title: Therapeutic Antibodies 3
Session Date and Time: April 17, 2023 – 1:30 PM – 5:00 PM
Location: Poster Section 24
Poster Board Number: 2

Poster OSE-127

Title: "CD127 is expressed by acute lymphoblastic leukemias and is efficiently targeted by the IL7R-antagonist OSE-127 through macrophage-mediated antibody dependent phagocytosis"
Session Category: Immunology
Session Title: Therapeutic Antibodies 3
Session Date and Time: April 17, 2023 – 1:30 PM – 5:00 PM
Location: Poster Section 24
Poster Board Number: 4

In parallel, OSE-127 is currently being developed in clinical stage in partnership with Servier. Two clinical studies are ongoing in inflammatory diseases: a phase 2a study conducted in primary Sjögren’s syndrome by Servier, for which completion of patient enrollment has been announced in November 2022, and a Phase 2 study conducted in ulcerative colitis by OSE Immunotherapeutics.

Poster BI 765063

Title: "Predictive response biomarkers from Phase I clinical trial of a SIRPalpha inhibitor BI765063, stand-alone and in combination with ezabenlimab, a PD1 inhibitor, in patients with advanced solid tumors"
Session Category: Clinical Research Excluding Trials
Session Title: Biomarkers of Therapeutic Benefit 2
Date & Time: April 17, 2023 – 9:00 AM – 12:30 PM
Location: Poster Section 39, Poster Board 3
Poster Number: 2129

BI 765063 is being evaluated in combination with Ezabenlimab in a Phase 1 expansion clinical trial in patients with microsatellite stable (MSS) advanced colorectal cancer and MSS advanced endometrium cancer whose disease relapsed after standard of care and who received no prior anti-PD-L1 inhibitors.

This Phase 1 clinical trial with BI 765063 is conducted by OSE Immunotherapeutics as part of a collaboration and license agreement under which Boehringer Ingelheim obtained exclusive rights to BI 765063.

* Collaborative academic program between OSE Immunotherapeutics and Dr Elise Chiffoleau’s research teams (Center for Research in Transplantation and Translational Immunology (CR2TI), UMR1064, INSERM, Nantes University at Nantes University Hospital, View Source).