Reata Pharmaceuticals, Inc. to Report Fourth Quarter and Full Year 2020 Financials and to Provide an Update on Development Programs on March 1, 2021

On February 22, 2021 Reata Pharmaceuticals, Inc. (Nasdaq: RETA) ("Reata," the "Company," or "we"), a clinical-stage biopharmaceutical company, reported that it will report financial results and provide an update on recent progress on its development programs pre-market on March 1, 2021 (Press release, Reata Pharmaceuticals, FEB 22, 2021, View Source [SID1234575387]).

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Reata’s management will host a conference call on March 1, 2021 at 8:30 am ET. The conference call will be accessible by dialing (866)270-1533 (toll-free domestic) or (412)317-0797 (international) using the access code: 10152707. The webcast link is View Source

Fourth quarter and full year 2020 financial results to be discussed during the call will be included in an earnings press release that will be available on the company’s website shortly before the call at View Source and will be available for 12 months after the call. The audio recording and webcast will be accessible for at least 90 days after the event at View Source.

HOPPS Payment Rate Error for CERIANNA™ (Fluoroestradiol F-18) Injection confirmed

On February 22, 2021 Zionexa reported that it has been working with SNMMI to seek proper Medicare reimbursement for Cerianna, radiolabeled 18F-fluoroestradiol indicated for use with positron emission tomography (PET) imaging for detection of estrogen receptor–positive lesions as an adjunct to biopsy in patients with recurrent or metastatic breast cancer (Press release, Zionexa, FEB 22, 2021, View Source [SID1234575386]). As of January 2021, the HOPPS published rate for this product is incorrect. Recently, the Centers of Medicare and Medicaid Services (CMS) confirmed their error in a HOPPS correction notice. The correct rate is $626.583 per millicurie instead of $0.752 per millicurie.

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CMS has told us that any corrections would be retroactive to January 1, 2021. SNMMI will notify their members and update the Q&As when any corrections are implemented. If you are encountering issues with your MAC, please notify SNMMI at [email protected].

Y-mAbs Therapeutics, Inc. Announces Closing of Public Offering and Full Exercise of the Underwriters’ Option to Purchase Additional Shares

On February 22, 2021 Y-mAbs Therapeutics, Inc. (the "Company" or "Y-mAbs") (Nasdaq: YMAB), a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, antibody-based therapeutic products for the treatment of cancer, reported the closing of its public offering of 2,804,878 shares of its common stock, at a public offering price of $41.00 per share, which includes the exercise in full of the underwriters’ option to purchase 365,853 additional shares of common stock (Press release, Y-mAbs Therapeutics, FEB 22, 2021, View Source [SID1234575385]). The aggregate gross proceeds to Y-mAbs, before deducting underwriting discounts and commissions and estimated offering expenses payable by the Company, were approximately $115 million. All of the shares of common stock were offered by the Company. Y-mAbs’ common stock is listed on The Nasdaq Global Select Market under the ticker symbol "YMAB."

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J.P. Morgan, Morgan Stanley and BofA Securities acted as the joint book-running managers for the offering. H.C. Wainwright & Co. and Kempen & Co acted as lead co-managers for the offering.

A preliminary prospectus supplement relating to and describing the terms of the offering was filed with the Securities and Exchange Commission ("SEC") on February 16, 2021. A final prospectus supplement relating to the offering was filed with the SEC on February 18, 2021. Copies of the final prospectus supplement relating to the offering are available on the SEC’s website at www.sec.gov. The final prospectus supplement and prospectus relating to the offering may be obtained from: J.P. Morgan, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY, 11717, or by telephone at (866) 803-9204; Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, Second Floor, New York, New York 10014 or BofA Securities, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, NC 28255-0001, Attn: Prospectus Department, or by emailing [email protected].

The shares of common stock described above are being offered by Y-mAbs pursuant to its shelf registration statement on Form S-3 (Reg. No. 333-234034), including a base prospectus, that was filed with the SEC on October 1, 2019 and declared effective by the SEC on October 15, 2019. The securities are being offered only by means of a prospectus supplement and accompanying prospectus forming a part of the effective registration statement. This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Vaccinex Announces Licensing of Anti-CCR8 Antibody to Surface Oncology

On February 22, 2021 Vaccinex, Inc. (Nasdaq: VCNX), a clinical-stage biotechnology company pioneering a differentiated approach to treating cancer and neurodegenerative disease through the inhibition of SEMA4D, reported that Surface Oncology will be exercising its option to license the anti-CCR8 antibody discovered via Vaccinex’s ActivMAb antibody discovery and novel viral display platform (Press release, Vaccinex, FEB 22, 2021, View Source [SID1234575384]). The antibody, SRF114, is a fully human IgG1 anti-CCR8 antibody that selectively depletes immuno-suppressive tumor T regulatory cells (Tregs) while sparing peripheral Tregs. The terms of agreement with Surface Oncology provided that Surface Oncology pay technology access and licensing fees in addition to research funding, and that Vaccinex will qualify for development milestone payments and royalties.

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"We are thrilled to continue building on the recent success of our ActivMAb platform with the announcement of our licensing deal with Surface Oncology," said Ernest Smith, chief scientific officer of Vaccinex. "The presence of Treg in human tumors is associated with resistance to immunotherapy and blocking CCR8 has been demonstrated to potentiate inhibition of tumor growth in animal studies. Data presented at SITC (Free SITC Whitepaper) 2020 demonstrated that SRF114 specifically binds to human CCR8 and induces Treg destruction through antibody-dependent cellular cytotoxicity. We are pleased to have played a part in the development of this promising drug candidate and look forward to following continuing development of SRF114 and further interactions with Surface Oncology."

About ActivMAb
ActivMAb was developed by Vaccinex and is a proprietary mammalian cell-based antibody discovery and novel viral display platform. The technology has multiple applications, including discovery of antibodies specific for complex membrane antigens, discovery of antibodies with optimized developability, and protein optimization for expression and activity. Its novel capabilities enable selection of unique antibody drugs against difficult high-value targets, including multi-pass membrane proteins against which small molecule drugs have demonstrated low efficacy or high toxicity.

Syros to Participate in Upcoming Investor Conferences in March

On February 22, 2021 Syros Pharmaceuticals (NASDAQ:SYRS), a leader in the development of medicines that control the expression of genes, reported that members of its management team will participate in panel discussions and present a corporate overview at upcoming investor conferences. Details are as follows (Press release, Syros Pharmaceuticals, FEB 22, 2021, View Source [SID1234575383]):

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Cowen and Company 41st Annual Health Care Conference
Date: Monday, March 1
Panel Title: Novel Oncology Targets
Panel Time: 1:20 p.m. ET

33rd Annual Roth Conference
Date: Monday, March 15
Panel Title: Navigating Clinical Development in RARE Hematologic & Inflammatory Disease
Panel Time: 10:00 a.m. ET

Oppenheimer 31st Annual Healthcare Conference
Date: Tuesday, March 16
Presentation Time: 8:40 a.m. ET

Live webcasts of the Roth and Oppenheimer presentations will be available on the Investors & Media section of the Syros website at www.syros.com. Archived replays of the webcasts will be available for approximately 30 days following each presentation.