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NANOBIOTIX to Participate in Fireside Chat at the Jefferies Virtual Healthcare Conference

On May 26, 2021 NANOBIOTIX (Euronext : NANO –– NASDAQ: NBTX – the ‘‘Company’’), a late-clinical stage biotechnology company pioneering physics-based approaches to expand treatment possibilities for patients with cancer, reported that Laurent Levy, co-founder and chief executive officer, will discuss the Company’s latest corporate and clinical developments in a fireside chat at the Jefferies Virtual Healthcare Conference on the 4th of June at 8:00 AM Eastern Time (14:00 Central European Time) (Press release, Nanobiotix, MAY 26, 2021, View Source [SID1234580643]).

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A live webcast of the discussion, as well as an archived recording may be accessed by visiting the events section of the Company’s website.

Brooklyn ImmunoTherapeutics CEO Howard J. Federoff Provides Roadmap for the Company’s Future During May 25, 2021 Shareholder Update Call

On May 26, 2021 -Brooklyn ImmunoTherapeutics, Inc. (NYSE American: BTX) ("Brooklyn"), a biopharmaceutical company currently focused on exploring the role that cytokine and gene editing/cell therapy can have in treating patients with cancer and blood disorders, reported that investors to review the Company’s shareholder update conference call presentation via its website, which can be found here (Press release, Brooklyn ImmunoTherapeutics, MAY 26, 2021, View Source [SID1234580642]).

Highlights include:

A review of the company’s multiple programs, including its unique Phase 2 mixed cytokine asset, IRX-2, being developed for head and neck cancer
A discussion of its recently acquired license for mRNA cell reprogramming technology, mRNA-based gene editing, proprietary gene editing protein and proprietary lipid delivery system, which the company believes may provide a completely different approach to treating certain solid tumors, liquid tumors, sickle cell disease and a host of other inherited monogenic disorders that may have no currently available therapy
An overview of the company’s current financial position and future financial plans

GM-CSF Gene-Edited CAR-T Data to be Presented at International Society for Cell & Gene Therapy Annual Meeting 2021

On May 26, 2021 Humanigen, Inc. (Nasdaq: HGEN), a clinical-stage biopharmaceutical company focused on preventing and treating an immune hyper-response called ‘cytokine storm’ with its lead drug candidate, lenzilumab, reported that granulocyte macrophage-colony stimulating factor (GM-CSF) gene-edited CAR-T data will be presented at the International Society for Cell & Gene Therapy (ISCT) 2021 Annual Meeting which will be held in New Orleans from May 26- 28, 2021 (Press release, Humanigen, MAY 26, 2021, View Source [SID1234580641]).

Researchers at the Mayo Clinic, Rochester, MN have demonstrated that CRISPR/Cas9 GM-CSF knock-out in CAR-T cells (GM-CSFKO CAR-T) dampens CAR-T cell early activation and reduces activation-induced cell death (AICD), resulting in enhanced antigen-specific T-cell expansion in vivo. The modulation of intrinsic pathways is not due to an off-target effect and provides additional mechanistic rationale for the improved anti-tumor activity observed with GM-CSFKO CAR-T.

"These findings highlight the intrinsic value of GM-CSFKO CAR-T as a novel, potentially more effective and less toxic platform to enhance current CAR-T cell therapies," said Cameron Durrant, MD, MBA, chief executive officer of Humanigen.

Mayo Clinic researchers will present their research entitled, "GM-CSF disruption in CAR-T cells ameliorates CAR-T cell activation and reduces activation-induced cell death," on May 28, 2021 from 11:30 AM to 1:00 PM ET as part of the session titled "Novel Allo-Engineering Approaches and Progress in Off-the-Shelf Products."

"Mayo Clinic is enthusiastic about these findings, and they provide us with valuable information to enhance our current CAR-T cell therapies," said Saad S. Kenderian, MD, Division of Hematology, Mayo Clinic.

Details for the upcoming event are below:

ISCT 2021 New Orleans VIRTUAL Meeting

Novel Allo-Engineering Approaches and Progress in Off-the-Shelf Products Session
Date: Friday, May 28, 2021
Time: 11:30 AM ET

Aptorum Group CEO Subscribed Shares In The Company

On May 26, 2021 Aptorum Group Limited (NASDAQ: APM, Euronext Paris: APM) ("Aptorum Group", the "Company"), a clinical-stage biopharmaceutical company focused on the development of novel therapeutics to address global unmet medical needs, reported that Mr. Ian Huen, Founder, Chief Executive Officer and Executive Director of the Company, through his wholly owned investment company Jurchen Investments Limited, has purchased an aggregate of 1,387,925 Class A Ordinary Shares in the Company at $2.882 per share, representing a 10% premium to the last closing price (Press release, Aptorum, MAY 26, 2021, View Source [SID1234580640]).

"Further to our ALS-4 and SACT-1 updates early this week, I am pleased to say that our leading programs are remaining on track with positive progress," said Mr. Huen. "I believe that my latest subscription demonstrates my steadfast confidence in the Company and I look forward for the Company to continue to deliver the exciting catalysts in 2021 and beyond."

Verseau Therapeutics Appoints John Edwards as Chief Executive Officer

On May 26, 2021 Verseau Therapeutics, Inc. reported the appointment of John Edwards as Chief Executive Officer (Press release, Verseau Therapeutics, MAY 26, 2021, View Source [SID1234580639]). John brings over 30 years of biopharmaceutical leadership experience and has been involved in the discovery, development or global commercialization of 10 FDA-approved biologics and eight biotech companies with successful exits .

"John has a proven track record of guiding biotech companies through pivotal growth points during all stages of development, including taking companies from discovery to clinical stage and through newly marketed therapies reaching patients," said Verseau Board member Robert Langer, who co-founded Verseau in 2017 with Tatiana Novobrantseva, Igor Feldman, and Dan Anderson. "We welcome John to the Verseau team and look forward to benefitting from his experience as the company pursues its mission to develop an important new class of cancer immunotherapies based on macrophage repolarization."

"Repolarizing macrophages not only leads to a direct attack on tumor cells, but also sets in motion a coordinated immune response to attract and turn on other important cancer-fighting immune cells in the tumor microenvironment," said John. "This breakthrough approach could expand the potential of immunotherapy across more tumor indications and benefit a greater number of patients compared to current T-cell-targeting therapies. I am honored to join Verseau and to help guide the company’s trajectory as it rapidly progresses toward clinical trials later this year."

John previously served as Executive Chair at Tilos Therapeutics, where in less than two years he helped advance the company from its formation to its acquisition by Merck. John has also served as Executive Chair of F-star, where he helped grow the company from discovery-stage to a leading developer of clinical-stage bispecific antibodies, which included bringing over $200M in revenue from business development deals. John has also played a key role in building Siamab and Exonics, both having successful M&A exits in 2019. During his tenure as Chief Operating Officer at Adnexus, he took the company from start-up through a $450M acquisition by Bristol Myers Squibb. Following the acquisition, he served as President of Adnexus and worked within BMS during the early days of immuno-oncology. John also previously held the role of Vice President of Sales, Marketing, and Medical Affairs at Transkaryotic Therapies and served a 15-year tenure with Genetics Institute/Wyeth, where he was responsible for leading the company’s first product from research to FDA and EMA approvals. John started his career as one of the first employees at Genzyme. In addition to his role at Verseau, John is Executive Chair at Abcuro. John received his MBA from Boston University and his B.S. in chemical engineering from the University of Massachusetts, Amherst.