1stOncology™: Cancer Intelligence Service – Page 10300 – 1stOncology is recognized as a Top 10 Global Pharma Analytic Provider

Labcorp Appoints Dr. Deborah Ann Sesok-Pizzini as Chief Medical Officer, Labcorp Diagnostics

On January 19, 2021 Labcorp, (NYSE: LH), a leading global life sciences company, reported that Dr. Deborah Ann Sesok-Pizzini has been appointed Chief Medical Officer of Labcorp Diagnostics, following the retirement of Dr. Dot Adcock in April 2021 (Press release, LabCorp, JAN 19, 2021, View Source [SID1234574093]). Dr. Sesok-Pizzini assumed the role starting on January 11, 2021.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

Schedule Your 30 min Free Demo!

Dr. Sesok-Pizzini joins Labcorp with over two decades of experience in healthcare. Prior to joining Labcorp, she held multiple appointments with The Children’s Hospital of Philadelphia, including Patient Safety Officer, Chief of the Division of Transfusion Medicine and Vice-Chief of Pathology and Laboratory Medicine. She was also a professor of clinical pathology and laboratory medicine at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, PA.

"We are thrilled to welcome Dr. Sesok-Pizzini to Labcorp," said Dr. Brian Caveney, chief medical officer and president of Labcorp Diagnostics. "Her significant contributions to scientific communities and research, along with her esteemed career in healthcare and pathology, will provide invaluable expertise and insight to our leadership team. We are also extremely grateful to Dr. Dot Adcock for her dedication and years of stellar service to Labcorp and wish her the best in retirement."

Dr. Sesok-Pizzini holds her doctorate from Pennsylvania State University and a MBA from Villanova University. She belongs to an extensive list of professional and scientific organizations and has authored dozens of articles, abstracts and publications related to her research.

"I am excited to be joining Labcorp Diagnostics and look forward to helping further the mission to improve health and improve lives," said Dr. Sesok-Pizzini. "My top priority has always been the patient. I hope to use my experiences and education to provide insights that can be used to enhance the patient experience, enable health provider decisions and develop innovative testing solutions."

Beam Therapeutics Inc. Announces $260 Million Common Stock Investment from Multiple Investors

On January 19, 2021 Beam Therapeutics Inc. (Nasdaq: BEAM) (the "Company"), a biotechnology company developing precision genetic medicines through base editing, reported that it has agreed to sell 2,795,700 shares of its common stock to certain institutional investors in a private placement (Press release, Beam Therapeutics, JAN 19, 2021, View Source [SID1234574092]). The Company anticipates aggregate gross proceeds from the offering will be approximately $260 million, before deducting fees to the placement agents and other estimated offering expenses payable by the Company, based on the offering price of $93.00 per share, representing an approximately 10% discount to the 5-day volume weighted average share price. The financing syndicate includes Perceptive Advisors, Farallon Capital, Casdin Capital, Redmile Group and Cormorant Asset Management, among others. The closing is anticipated to occur on January 21, 2021, subject to customary closing conditions. The Company intends to use the net proceeds from the offering to support clinical development, to pursue strategic partnerships and general corporate purposes.

J.P. Morgan acted as lead placement agent and William Blair acted as joint placement agent.

The securities are being sold in a private placement and have not been registered under the Securities Act of 1933, as amended (the "Securities Act"), and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements. The Company has agreed to file a resale registration statement with the Securities and Exchange Commission (the "SEC"), for purposes of registering the resale of the shares of common stock issued or issuable in connection with the offering.

This press release does not constitute an offer to sell or the solicitation of an offer to buy the securities, nor shall there be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such state. Any offering of the securities under the resale registration statement will only be by means of a prospectus.

Lilly and Merus NV Announce Collaboration to Discover Novel T-Cell Re-Directing Bispecific Antibodies

On January 19, 2021 Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Merus N.V. (NASDAQ: MRUS), a clinical-stage oncology company developing multi-specific antibodies, reported a research collaboration and exclusive license agreement that will leverage Merus’ proprietary Biclonics platform along with the scientific and rational drug design expertise of Loxo Oncology at Lilly to research and develop up to three CD3-engaging T-cell re-directing bispecific antibody therapies (Press release, Eli Lilly, JAN 19, 2021, View Source [SID1234574091]).

Under the terms of the agreement, Merus will lead discovery and early stage research activities while Loxo Oncology at Lilly will be responsible for additional research, development and commercialization activities. Merus will receive an upfront cash payment of $40 million, as well as an equity investment by Lilly of $20 million in Merus common shares. Merus is also eligible to receive up to $540 million in potential development and commercialization milestones per product, for a total of up to approximately $1.6 billion for three products, as well as tiered royalties ranging from the mid-single to low-double digits on product sales should Lilly successfully commercialize a therapy from the collaboration.

"CD3-engaging bispecific antibodies are rapidly becoming one of the most transformative immune-modulating modalities used to treat cancer. We expect these therapies will become an important component of the Loxo Oncology at Lilly biologics strategy," said Jacob Van Naarden, chief operating officer of Loxo Oncology at Lilly. "Merus has built a differentiated platform and one that we believe can enable us to create bispecific antibody therapies with wider therapeutic indexes than those available today. We look forward to working closely with Merus to develop new potential medicines for patients with cancer."

"The collaboration with Loxo Oncology at Lilly and their world class research capabilities opens up exciting possibilities for Merus’ Biclonics platform," said Bill Lundberg, MD., President and Chief Executive Officer at Merus. "Our CD3 T-cell engager platform includes over 175 novel and diverse anti-CD3 common light chain antibodies across a wide range of affinities and attributes and enables functional screening of large libraries for optimal performance. We look forward to working together with Loxo Oncology at Lilly to define a new generation of medicines to treat cancer."

This transaction is subject to customary closing conditions. This transaction will be reflected in Lilly’s reported results and financial guidance according to Generally Accepted Accounting Principles (GAAP). There will be no change to Lilly’s 2021 non-GAAP earnings per share guidance as a result of this transaction.

HSA approval for Phase 1 IND clinical trial for Lion TCR’s lead product LioCyx-M to characterize changes in liver cancer tumor microenvironment

On January 19, 2021 Lion TCR reported that Health Sciences Authority (HSA) has granted approval for our local open label, single-arm, single center Phase 1 Investigational New Drug (IND) clinical trial application to further analyze liver cancer tumor microenvironment (TME) (Press release, Lion TCR, JAN 19, 2021, View Source [SID1234574089]).

Study name: Phase 1 Safety and Tolerability Study of Redirected HBV-Specific T-Cells in Patients with Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (SAFE-T-HBV)
Protocol No.: LTCR-HCC-3-3
Certificate number: CTC2100001
Approval date: 04 January 2021
Product: LioCyx-M (Autologous T-cells transfected with mRNA encoding HBV antigen-specific TCR)

Lion TCR has pioneered the use of mRNA to engineer T cells as an anti-tumor therapy. Our lead product LioCyx-M consists of a preparation of autologous T-cells transfected with mRNA encoding HBV antigen-specific TCR. These HBV-TCR engineered T cells are able to transiently recognize and lyse HBV-expressing hepatocellular carcinoma cells. We have previously studied the safety and preliminary efficacy of LioCyx-M both in patients with recurrent HBV-related hepatocellular carcinoma (HCC) post liver transplant [1] and in patients with advanced primary HBV-related HCC [2].

In this new study, we aim to determine, in unresectable patients with HBV-related primary HCC, the capability of LioCyx-M to not only directly lyse HCC cells expressing HBV antigens but also to alter HBV-related HCC microenvironment. Safety, HCC tumor volume reduction and alteration of tumor microenvironment will be sequentially monitor in treated patients. Preliminary results have suggested that LioCyx-M therapeutic efficacy might be linked to its ability to alter the tumor microenvironment (convert "cold tumours" to "hot tumours"). Hot tumours are characterized by the proinflammatory cytokines production and T-cell infiltration and are linked to longer survival. With a better understanding of the mechanism of action of LioCyx-M, we might be able to exploit LioCyx-M treatment to favor a more durable therapeutic efficacy in combination with other immunotherapy strategies such as immune checkpoint inhibitors.

This trial will be conducted at Singapore General Hospital (SGH) in collaboration with SGH Senior Consultant, Dr Thinesh Lee Krishnamoorthy and Professor Antonio Bertoletti from Duke-NUS Medicine School.

References
1. Chen W, Cheng J, Zheng X, et al 273 Phase I study of LioCyx-M, autologous hepatitis B virus (HBV)-specific T cell receptor (TCR) T-cells, in recurrent HBV-related hepatocellular carcinoma (HCC) post-liver transplantation. Journal for ImmunoTherapy of Cancer 2020;8:doi: 10.1136/jitc-2020-SITC2020.0273
2. Wang F, Meng F, Jin J, et al 272 Use of LioCyx-M, autologous hepatitis B virus (HBV)-Specific T cell receptor (TCR) T-cells, in advanced HBV-related hepatocellular carcinoma (HCC). Journal for ImmunoTherapy of Cancer 2020;8:doi: 10.1136/jitc-2020-SITC2020.0272

Prescient Therapeutics (ASX:PTX) to begin three next-gen CAR T programs

On January 19, 2021 Prescient Therapeutics (PTX) reported that three internal development programs for its immune receptor technology platform, OmniCAR (Press release, Prescient Therapeutics, JAN 19, 2021, View Source;utm_medium=rss&utm_campaign=prescient-therapeutics-asxptx-to-begin-three-next-gen-car-t-programs [SID1234574088]).

OmniCAR is a next-generation CAR T therapy platform that offers multiple advantages over its predecessor such as control, safety, flexibility and efficacy.

CAR T is a form of immunotherapy that uses T-cells to directly target cancer cells, however, it has some limitations. As a result, OmniCAR is believed to be a more safe and effective treatment when treating cancers such as Acute Myeloid Leukemia (AML), breast, ovarian and gastric cancers and glioblastoma multiforme (GBM).

Essentially, AML causes patients to become extremely ill, which makes them unable to tolerate the vigorous nature of CAR T therapy. The disease is also known to rapidly mutate mid-therapy, which causes single CAR Ts to be ineffective.

Other downsides of CAR T therapy when treating solid tumours include its inability to overcome an immunosuppressive tumour microenvironment and the inability of T-cells to reach tumour sites and penetrate physical barriers.

When considering GBM and its rapidly progressive nature, CAR Ts ability to only target a single antigen makes it an ineffective treatment option.

Following a strategic review by Prescient and its scientific advisory board, it has been realised that using the OmniCAR technology to treat these cancers may have significant benefits over the conventional CAR T therapy.

Benefits include titration for improved safety, the ability to switch antigen targeting; co-arming CAR T against multiple antigens simultaneously, persistent dosing and improved efficacy.

The development programs are OmniCAR CD33 and CLL-1 for AML, OmniCAR Her2 for Her2+ solid tumours including breast, ovarian and gastric cancers, and OmniCAR Her2 and EGFRviii for GBM.

"We are delighted to select these internal programs as truly differentiated, next-generation CAR T products for Prescient. Each of the programs represents a tremendous market opportunity," Prescient Therapeutics Managing Director and CEO Steven Yatomi-Clarke said.

"Furthermore, Prescient will continue to seek collaborations with external parties on additional opportunities where OmniCAR can create additional next-generation CAR therapies with partners," he added.

Not only are the programs aimed at demonstrating the unique features and advantages of OmniCAR in treating patients, but they’ll also potentially move OmniCAR towards clinical programs.

Company shares are up 5 per cent and trading at 8.4 cents at 11:10 am AEDT.