1stOncology™: Cancer Intelligence Service – Page 10340 – 1stOncology is recognized as a Top 10 Global Pharma Analytic Provider

BioMarin to Participate in the Credit Suisse 29th Annual Virtual Healthcare Conference on November 10 at 12:30pm ET

On November 4, 2020 BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) reported that Jean-Jacques Bienaimé, Chairman and Chief Executive Officer, and Brian Mueller, Executive Vice President, Chief Financial Officer, will participate in the Credit Suisse 29th Annual Virtual Healthcare Conference on November 10, 2020 at 12:30pm ET (Press release, BioMarin, NOV 4, 2020, View Source [SID1234569906]). An audio webcast of the presentation will be available live. You can access the webcast at: View Source An archived version of the remarks will also be available through the Company’s website for a limited time following the conference.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

Schedule Your 30 min Free Demo!

Evogene Announces Closing of $12 Million Registered Direct Offering

On November 4, 2020 Evogene Ltd. (NASDAQ: EVGN), (TASE: EVGN), a leading computational biology company focused on revolutionizing product discovery and development in multiple life-science based industries, including human health and agriculture, reported that it has closed the previously announced registered direct offering pursuant to which the company entered into a definitive securities purchase agreement with an existing institutional shareholder and certain Israeli institutional investors providing for the issuance of an aggregate of (i) 3.92 million ordinary shares at a purchase price of $2.50 per share, and (ii) 883,534 pre-funded warrants each to purchase one ordinary share ("Pre-Funded Warrants") (Press release, Evogene, NOV 4, 2020, View Source [SID1234569905]). The Pre-Funded Warrants were sold at a price of $2.49 each, with an exercise price of $0.01 per ordinary share. The Pre-Funded Warrants are exercisable at any time after the date of issuance upon payment of the exercise price.

Cantor Fitzgerald & Co. acted as placement agent in the offering.

The ordinary shares and Pre-Funded Warrants offered in the registered direct offering described above were offered by Evogene pursuant to its shelf registration statement on Form F-3 (File No.333-240249) previously filed and declared effective by the Securities and Exchange Commission (the "SEC") on August 10, 2020. A prospectus supplement and accompanying prospectus relating to the offering have been filed with the SEC and is available on the SEC’s website at View Source

This press release is for informational purposes only and should not be construed as investment advice and does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor will there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Shuttle Pharmaceuticals, Inc. Awarded a New Patent for Dual Function HDAC Molecules for HDAC Inhibition and Ataxia Telangiectasia Mutated Activation for Cancer Treatment

On November 4, 2020 Shuttle Pharmaceuticals, Inc (Shuttle Pharma) a clinical stage, Maryland-based, biopharmaceutical company developing new drugs for cancer treatment in combination with radiation therapy, reported that it was awarded patent number 10,745,352 by the U.S. Patent and Trademark Office (Press release, Shuttle Pharmaceuticals, NOV 4, 2020, View Source [SID1234569904]). These novel compounds enable cancer treatment by the combination of an inhibitory epigenetic mechanism and a stimulatory DNA repair activation process using a single molecule. The patent is the first issued based on Shuttle Pharma’s platform technology linking an ATM activating domain to an HDAC inhibitory domain for cancer treatment and protection of normal tissue. Shuttle Pharma holds the exclusive rights for development of this drug platform.

Lead inventor Scott Grindrod, PhD describes histone deacetylase (HDAC) inhibitors as a novel class of drugs targeting enzymes involved in regulation of gene expression. HDACs regulate gene expression by changing the conformation of chromatin in cells into a tightly coiled and transcriptionally inactive form. However, acetylated chromatin is more open and supports transcription. Inhibitors of HDAC enzymes can inhibit cell growth, regulate tubulin stability, turn on transcription of tumor suppressor genes, and activate cellular immunity. These are key target functions for cancer treatment.

Ataxia-telangiectasia is a human genetic disease characterized by extreme radiation sensitivity, neurological immune impairment, and premature aging. The mutated gene product (ATM) regulates the responses of cells to DNA damaging agents. In normal cells, ATM protein activation enables efficient repair of radiation damage to protect the genome and promote cell survival.

There are 12 HDAC enzymes with important functions for maintaining health. Clinical applications of pan-HDAC inhibitors have been limited by off target toxicities. Shuttle Pharma has focused its discovery platform technology on HDAC enzyme selectivity. According to Dr. Anatoly Dritschilo, Shuttle Pharma’s CEO, the interest in immunotherapy to treat cancers in combination with other modalities has focused particular attention on HDAC6 selective inhibitors.

Protagonist Therapeutics to Present Updated Clinical Data for Hepcidin Mimetic PTG-300 in Polycythemia Vera at the American Society for Hematology (ASH) 2020 Annual Meeting

On November 4, 2020 Protagonist Therapeutics, Inc. (NASDAQ: PTGX) reported the acceptance of one oral and four poster presentations at the American Society for Hematology (ASH) (Free ASH Whitepaper) annual meeting, taking place in a virtual format December 5-8, 2020 (Press release, Protagonist, NOV 4, 2020, View Source [SID1234569903]). The abstract data includes results as of early August 2020 from the ongoing Phase 2 study of PTG-300 in the treatment of polycythemia vera. Additional updated data from the study will be available during presentations at the conference.

"This year’s ASH (Free ASH Whitepaper) meeting provides an opportunity for Protagonist to share detailed findings of its PTG-300 hepcidin mimetic program for polycythemia vera (PV) at a major medical conference for the first time," commented Dinesh V. Patel, Ph.D., Protagonist President and Chief Executive Officer. "We look forward to presenting updated results from our ongoing Phase 2 PTG-300 proof-of-concept PV study at the conference. We will also present an analysis of real world patient data and potential unmet need in PV, as well as promising preclinical findings with a new oral hepcidin mimetic peptide. As a non-cytoreductive treatment option based on the activity of a natural hormone, PTG-300 has truly transformative potential for PV patients and we look forward to advancing PTG-300 on the path toward regulatory approval as efficiently as possible."

Oral presentation:

1) Title: PTG-300 Eliminates the Need for Therapeutic Phlebotomy in Both Low and High-Risk Polycythemia Vera Patients (Abstract #482)
Session: 634. Myeloproliferative Syndromes: Clinical: Clinical Trials in Polycythemia Vera
Session Date: Sunday, December 6, 2020
Presentation Time: 2:45 p.m. PST
Presenter: Marina Kremyanskaya, M.D., Ph.D., Icahn School of Medicine at Mount Sinai

Poster presentations:

2) Title: Hepcidin Mimetic (PTG-300) Reverses Iron Deficiency While Controlling Hematocrit in Polycythemia Vera Patients (Abstract #1689)
Session: 102. Regulation of Iron Metabolism: Poster II
Date: Sunday, December 6, 2020
Presenter: Yelena Ginzburg, M.D., Icahn School of Medicine at Mount Sinai

3) Title: Real-World Treatments and Thrombotic Events in Polycythemia Vera Patients: A Retrospective Analysis between 2018-2019 in US Population (Abstract #2998)
Session: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma—Clinical Studies: Poster III
Date: Monday, December 7, 2020
Presenter: Srdan Verstovsek, M.D., Ph.D., MD Anderson Cancer Center

4) Title: Mechanism of Systemic Iron Regulation and Hematocrit Control by Hepcidin Peptidomimetics in Pre-Clinical Models (Abstract #2594)
Session: 102. Regulation of Iron Metabolism: Poster III
Date: Monday, December 7, 2020
Presenter: Roopa Taranath, Ph.D., Protagonist Therapeutics

5) Title: Hepcidin Peptidomimetics – Oral Efficacy in Pre-Clinical Disease Model of Iron Overload (Abstract #2592)
Session: 102. Regulation of Iron Metabolism: Poster III
Date: Monday, December 7, 2020
Presenter: Roopa Taranath, Ph.D., Protagonist Therapeutics

Abstracts are available via the ASH (Free ASH Whitepaper) meeting website at View Source

CTI BioPharma Announces Oral Presentation at the 62nd American Society of Hematology Meeting

On November 4, 2020 CTI BioPharma Corp. (Nasdaq: CTIC) reported an oral presentation supporting the Company’s pacritinib development program in graft versus host disease (GVHD) at the 62nd American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting & Exposition, being held virtually December 5- 8, 2020 (Press release, CTI BioPharma, NOV 4, 2020, View Source [SID1234569902]).

The details of the presentation are as follows:

Abstract Title: Biological and Clinical Impact of JAK2/mTOR Blockade in GVHD Prevention: Preclinical and Phase I Trial Results
Session Name: Clinical Allogeneic Transplantation; Acute and Chronic GVHD, Immune Reconstitution Phase I and II Trials
Session Number: 722
Session Date: Sunday, December 6, 2020
Session Time: 9:30 a.m. – 11:00 a.m. PT
Presentation Time: 10:00 a.m. PT
Presenter: Dr. Joseph Pidala