Alexion to Report Third Quarter 2020 Results on Thursday, October 29, 2020

On October 20, 2020 Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN) reported that the Company will report its financial results for the third quarter ended September 30, 2020 before the US financial markets open on October 29, 2020 (Press release, Alexion, OCT 20, 2020, View Source [SID1234569967]). Following the release of the financial results, Alexion management will conduct a conference call and audio webcast from 8:00-9:00 a.m. Eastern Time (ET).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

To participate in this conference call, dial (866) 762-3111 (USA) or (210) 874-7712 (International), conference ID 6582445 shortly before 8:00 a.m. ET. The audio webcast can be accessed on the Investor page of View Source and an archived version will be available for a limited time following the presentation.

Vaccitech expands management team with hires including CMO and CFO

On October 20, 2020 Vaccitech Ltd, a clinical-stage biopharmaceutical company developing T cell vaccines and immunotherapies designed to treat and prevent infectious disease and cancer, reported the appointment of three new senior leaders across its clinical, financial and manufacturing operations during a period of significant growth for the company (Press release, Vaccitech, OCT 20, 2020, View Source [SID1234568968]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Margaret (Meg) Marshall, M.D. becomes Vaccitech’s full-time Chief Medical Officer, having worked as a consultant for the company since June 2020. Dr. Marshall has over 25 years of experience in the preclinical and clinical development of cell and antibody-based immunotherapy for infectious disease and cancer. Prior to joining Vaccitech, she held directorship positions in the clinical research departments of Kyowa Kirin, Kite Pharma and Pfizer. Dr. Marshall will lead the clinical development planning and execution of the company’s programs.

"It has been a great experience working for Bill and the team, and I’m thrilled to officially be on board to lead the clinical development of our exciting immunotherapy and vaccine programs. Our T cell-inducing platform has great potential to be transformative, and to deliver patient benefits in chronic infectious diseases such as HBV and HPV as well as in oncology indications such as prostate cancer and non-small cell lung cancer (NSCLC)," said CMO Dr. Meg Marshall.

Georgy Egorov joins Vaccitech as Chief Financial Officer. Mr. Egorov brings more than 20 years of senior finance, strategy, investment banking and capital markets experience as well as extensive knowledge of investor relations and corporate development to the company. Mr. Egorov joins Vaccitech from Exscientia, a global leader in AI drug discovery, where he was CFO and Board member. Mr. Egorov also worked in investment banking at Goldman Sachs and UBS, where he was involved in numerous M&A transactions and equity and debt financings.

CFO Georgy Egorov comments, "Despite the pandemic, 2020 has been an incredible year for investing in life sciences, with unprecedented amounts of capital raised. I look forward to ensuring Vaccitech stays on a firm financial footing as we expand our operations and seek to develop our T cell immunotherapy and vaccine product candidates from the clinic through to market, if approved."

In addition, Simon Alvis, Ph.D., joins Vaccitech as Vice President Manufacturing. Since 1999, Dr. Alvis has cultivated a broad expertise across process, analytical and formulation development of viral and recombinant protein biological drug products. He has great experience and strategic vision for the regulatory and manufacturing requirements necessary to move biologic product candidates forward towards commercialization. He joins Vaccitech after leading viral manufacturing programs at PsiOxus Therapeutics.

VP of Manufacturing, Simon Alvis adds, "We are planning for success and scale up at Vaccitech, and I am delighted to bring my manufacturing expertise to the company as we expand our clinical pipeline. I believe we can really make a difference to patients’ lives by treating and preventing infectious diseases and cancer."

Bill Enright, CEO of Vaccitech, said, "I am delighted to welcome aboard Meg, Georgy and Simon; their wealth of experiences driving product candidate development, financial management and manufacturing will be key to helping Vaccitech move its important immunotherapies forward."

Focus Fund and MD Anderson launch investment fund to support promising investigational cancer therapies in early-stage clinical trials

On October 20, 2020 The Focus Fund GP, LLC, in partnership with The University of Texas MD Anderson Cancer Center, reported that it has launched Cancer Focus Fund, LP, an oncology-focused investment fund designed to support the advancement of compelling investigational cancer therapies from late preclinical development through Phase I and Phase Ib/II clinical trials (Press release, MD Anderson, OCT 20, 2020, View Source [SID1234568958]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Small to midsize biopharmaceutical companies often face challenges in conducting effective early-stage clinical studies as a result of a lack of funding, as well as access to oncologists, clinical facilities and eligible patients seeking to participate in cancer trials. Cancer Focus Fund aims to address this unmet need by providing investments for promising cancer therapeutics together with the clinical trials expertise and infrastructure of MD Anderson. The goal is to accelerate the progress of these promising therapies through Investigational New Drug (IND) approval and Phase I and Phase Ib/II studies.

Cancer Focus Fund has held its initial closing with over $50 million of capital commitments. In addition to MD Anderson, Limited Partners include the Baton Rouge Area Foundation, Rice University Endowment, LSU Health Shreveport Foundation, Ochsner Health and other private investors.

"The Cancer Focus Fund is a unique investment fund that aligns the scientific and clinical expertise of MD Anderson with business experts, public financing entities and private venture capital to propel promising cancer therapies toward pivotal trials," said Ross Barrett, a founder and Managing Partner of Cancer Focus Fund. "We are delighted to work with MD Anderson in this effort and are optimistic that our approach will help companies successfully conduct clinical trials and bring more novel treatments to patients. We also believe our unique approach has the potential to reward our investors and thereby provide incentives for further investments in innovative cancer therapies."

Cancer Focus Fund is jointly administered by a scientific advisory committee, made up of MD Anderson researchers and physicians, and an investment committee, composed of experienced biotechnology investment professionals. The scientific committee will consider candidates from worldwide sources for potential investment based on scientific merit, and the investment committee will make final decisions on funding based on those recommendations.

"We are committed to bringing forward the most impactful new therapies that will improve the lives of our patients," said Ferran Prat, Ph.D., J.D., senior vice president for Research Administration and Industry Relations at MD Anderson. "Without appropriate support, we know that some therapies with great potential may be delayed, may not be developed properly in the clinical setting or may never make it into clinical studies. Through investment from the Cancer Focus Fund and the support of MD Anderson, we hope to advance worthwhile new treatments past the traditional hurdles in the drug development process to the patients who need them."

As part of the partnership, MD Anderson will design and host clinical studies for therapies that receive IND approval, utilizing the extensive expertise of MD Anderson physicians in conducting early stage clinical trials. In addition, Ochsner Health and LSU Health Shreveport, which serve large numbers of cancer patients, will work with Cancer Focus Fund portfolio companies to provide additional clinical trial sites so that patients can join clinical studies as appropriate.

"Through the Gayle and Tom Benson Cancer Center at Ochsner, the Precision Cancer Therapies Program offers the only program in our region dedicated to offering early phase clinical trials for cancer patients," said Leonardo Seoane M.D. Chief Academic Officer and Senior Vice-President Ochsner Health. "We are very excited to partner with the Cancer Focus Fund to help develop new therapies to treat cancer and provide these clinical trials closer to our communities."

"The Feist-Weiller Cancer Center at LSU Health Shreveport is excited to be a part of the Cancer Focus Fund to bring the latest new cancer clinical trials to our community," said Dr. Chris Kevil, Vice-Chancellor for Research at LSU Health Shreveport. "We are confident our clinical trial facilities, coupled with expanded patient access to clinical trials across north and central Louisiana in partnership with Ochsner Health, will yield promising results for all citizens of Louisiana."

Cytocom and Cleveland BioLabs Announce Definitive Merger Agreement

On October 20, 2020 Cytocom, Inc. (Cytocom), a leading biopharmaceutical company in the area of immune-modulation, and Cleveland BioLabs, Inc., (NASDAQ: CBLI), an innovative biopharmaceutical company developing novel approaches to activate the immune system, reported that they have entered into a definitive merger agreement to combine their businesses in an all-stock transaction (Press release, Cytocom, OCT 20, 2020, https://www.cytocom.com/2020/10/20/cytocom-and-cleveland-biolabs-announce-definitive-merger-agreement/?utm_source=rss&utm_medium=rss&utm_campaign=cytocom-and-cleveland-biolabs-announce-definitive-merger-agreement [SID1234568915]). Cytocom shareholders will have a majority position in the newly combined entity, which the parties anticipate will continue to be listed on the Nasdaq, and the initial Board of Directors for the combined company will consist of four members selected by Cytocom and three members selected by Cleveland BioLabs. The Boards of Directors of both companies have approved the combination.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Each party to the proposed merger believes that the combined company will create near-term commercial opportunities in numerous areas of significant unmet medical needs including acute radiation injury, oncology, infectious disease, inflammation and autoimmune-mediated conditions, with multiple commercial, regulatory and clinical milestones expected over the next 12 to 18 months. Operating as "Cytocom, Inc." and under the leadership of Cytocom’s experienced management team, the combined company will be positioned for consistent growth.

Overview

Michael K. Handley, President and Chief Executive Officer of Cytocom, stated, "Our merger with Cleveland BioLabs and its subsequent immune-focused platform will be a transformative growth opportunity for Cytocom and Cleveland BioLabs shareholders. We believe that the combination of these highly complementary late-stage pipelines will strengthen our position and advance our efforts to unlock the potential of immune-modulating agents in the treatment of serious medical conditions. Further, this merger will enhance our ability to become a recognized leader in immune-modulating treatments and builds on the momentum created by our recent acquisition of ImQuest Life Sciences. We plan to utilize the combined platform to further drive value with additional clinical and commercial products and continue to seek strategic partnerships and acquisitions."

Dr. Andrei Gudkov, Chief Scientific Officer of Cleveland BioLabs, said: "This is an exciting day for Cleveland BioLabs and a great opportunity for our stockholders. The merger with Cytocom will allow us to add the strength of our science and bright perspectives associated with Entolimod development in cancer treatment and radiation defense arenas with a string of immunomodulators developed by Cytocom to form a powerful blend of conceptually and scientifically aligned products. We believe that the merger with Cytocom is the ideal way to unlock the value of our technology platform and our lead drug candidate, Entolimod, and I look forward to seeing this exciting new therapy advance through the clinic."

Conditions

The proposed transaction is subject to customary closing conditions, including approval by the stockholders of Cleveland Biolabs, the shares of the combined company being approved for listing on Nasdaq and a registration statement under the Securities Act becoming effective. Cytocom and Cleveland Biolabs expect the transaction to close during the first quarter of 2021.

Conference Call

Cytocom will host a conference call and live audio webcast at 8:00 a.m. EDT on October 28th to discuss the merger and provide a strategic vision for the combined company. To access the conference call supported with slides, please dial 646-558-8656 with the meeting ID: 841 7826 2704 and passcode: 281020. The conference call can also be accessed at https://cleartrustonline.com/cytocom. Approximately two hours following the live event, a webcast replay of the conference call will be available on Cytocom’s website https://www.cytocom.com/investors/ for approximately 30 days.

WindMIL Therapeutics Announces Marrow-Infiltrating Lymphocytes (MILs®) Data Selected for Poster Presentation at the Society for Immunotherapy of Cancer (SITC) 35th Anniversary Annual Meeting

On October 20, 2020 WindMIL Therapeutics, a clinical-stage company developing marrow-infiltrating lymphocyte (MILs) products for cancer immunotherapy, reported that data regarding MILs as a potential cancer immunotherapy for hematological and solid tumors has been selected for a poster presentation at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 35th Anniversary Annual Meeting which will take place virtually November 9 – 14, 2020 (Press release, WindMIL Therapeutics, OCT 20, 2020, View Source [SID1234568826]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Details of the presentation are as follows:

Title: Marrow-infiltrating Lymphocytes (MILs): A Novel Adoptive Immunotherapy for Hematological and Solid Tumors
Abstract ID: 14151
Presenter: Eric Lutz, PhD, Director of Research, WindMIL Therapeutics

A copy of the abstract can be viewed online through the SITC (Free SITC Whitepaper) website. The presentation will be available in the Virtual Poster Hall from November 9 – 14, 2020.