Athenex, Inc. Announces Pricing of $110 Million Public Offering of Common Stock

On September 10, 2020 Athenex, Inc. (Nasdaq: ATNX), a global biopharmaceutical company dedicated to the discovery, development and commercialization of novel therapies for the treatment of cancer, reported the pricing of a public offering of 10,000,000 shares of its common stock at a public offering price of $11.00 per share (Press release, Athenex, SEP 10, 2020, View Source [SID1234573872]). The gross proceeds to Athenex from the offering, before underwriting discounts and commissions and estimated offering expenses, are expected to be $110 million. In addition, Athenex has granted the underwriters a 30-day option to purchase up to an additional 1,500,000 shares of common stock at the public offering price, less underwriting discounts and commissions. The offering is expected to close on September 14, 2020, subject to customary closing conditions.

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Athenex intends to use the net proceeds from the proposed offering to continue to expand and strengthen its commercial infrastructure, execute label expansion strategies for Oral Paclitaxel, advance the development of its product candidates, invest in its CMC development for its product candidates and manufacturing infrastructure, and fund working capital and other general corporate purposes.

SVB Leerink, RBC Capital Markets and Evercore ISI are acting as joint book-running managers and Oppenheimer & Co. is acting as lead manager for the offering.

The securities described above are being offered by Athenex pursuant to a shelf registration statement on Form S-3 (File No. 333-227492) that was filed with the Securities and Exchange Commission (the "SEC") on September 24, 2018 and became effective upon filing. The offering will be made only by means of a written prospectus and a prospectus supplement that form a part of the registration statement. A preliminary prospectus supplement relating to and describing the terms of the offering was filed with the SEC and is available on the SEC’s website at www.sec.gov. A final prospectus supplement and the accompanying prospectus relating to this offering will be filed with the SEC and will be available at www.sec.gov. When available, copies of the final prospectus supplement and accompanying prospectus may also be obtained from: SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at 1-800-808-7525, ext. 6218, or by email at [email protected]; RBC Capital Markets, LLC, Attention: Equity Syndicate, 200 Vesey Street, 8th Floor, New York, NY 10281, by telephone at (877) 822-4089, or by email at [email protected]; and Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 36th Floor, New York, New York 10055, or by telephone at (888) 474-0200, or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there by any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

Cellectar Biosciences to Present at Two Upcoming Investor Conferences

On September 10, 2020 Cellectar Biosciences, Inc. (NASDAQ: CLRB), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, reported James Caruso, president and CEO, will present at the following investor conferences in September and be available for 1×1 meetings (Press release, Cellectar Biosciences, SEP 10, 2020, View Source [SID1234569924]):

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H.C. Wainwright 22nd Annual Global Investment Conference
Date: Tuesday, September 15, 2020
Time: 3:30 pm Eastern Time
Format: Virtual Presentation and 1×1 meetings

Oppenheimer Fall Healthcare Life Sciences & MedTech Summit
Date: Monday, September 21, 2020
Time: 4:10 pm Eastern Time
Format: Virtual Presentation and 1×1 meetings

A replay of the presentation and webcast will be on the Investor Relations section of the company’s website available for 90 days here.

Ziopharm Oncology to Participate in Upcoming Conferences

On September 10, 2020 Ziopharm Oncology, Inc. (Nasdaq: ZIOP), reported that Laurence Cooper, M.D., Ph.D., Chief Executive Officer of Ziopharm, is scheduled to participate in two upcoming conferences (Press release, Ziopharm, SEP 10, 2020, View Source [SID1234569923]):

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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H.C. Wainwright 22nd Annual Global Investment Conference
Date: Wednesday, September 16, 2020
Time: 9:00 a.m. ET (presentation)

Cantor Virtual Global Healthcare Conference
Date: Thursday, September 17, 2020
Time: 1:20 p.m. ET (fireside chat)
To access the live webcast presentations, or the subsequent archived recordings, please visit the "Investors" section of the Ziopharm website at www.ziopharm.com.

AIM ImmunoTech to Present at the H.C. Wainwright 22nd Annual Global Investment Conference on September 14th

On September 10, 2020 AIM ImmunoTech Inc. (NYSE American:AIM) reported that the company will be presenting at the H.C. Wainwright Annual Global Investment Conference, being held virtually on September 14-16, 2020 (Press release, AIM ImmunoTech, SEP 10, 2020, https://aimimmuno.com/press-release/aim-immunotech-to-present-at-the-h-c-wainwright-22nd-annual-global-investment-conference-on-september-14th/ [SID1234569678]).

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Thomas K. Equels, Chief Executive Officer of AIM ImmunoTech, is scheduled to present on Monday, September 14 at 5:00 p.m., Eastern Time. The presentation will be webcast live on the conference event platform, which can be accessed here.

Immatics Provides Update on IMA204 ACTengine® Cell Therapy Program Targeting the Tumor Microenvironment

On September 10, 2020 Immatics N.V. (NASDAQ: IMTX; "Immatics"), a clinical-stage biopharmaceutical company active in the discovery and development of T cell redirecting cancer immunotherapies, reported an update on its fourth ACTengine cell therapy program, IMA204 (Press release, Immatics Biotechnologies, SEP 10, 2020, View Source [SID1234569534]). IMA204 is designed to address a novel target, COL6A3 exon 6, which is highly expressed in the stroma of a large number of solid tumors. Immatics will discuss the IMA204 preclinical data at the Hanson Wade CAR-TCR Digital Week on September 14th.

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Preclinical data highlights:

Exon 6 of the protein COL6A3 is predominantly expressed in the tumor stroma of multiple solid cancers including pancreatic cancer, breast cancer, gastric cancer, sarcoma, esophageal cancer, non-small cell lung cancer, squamous head & neck cancer, colorectal cancer, mesothelioma, ovarian cancer and others with prevalence estimates in these cancer types in the range of 40-80%.
The tumor stroma target of IMA204 is an HLA-A*02-associated peptide derived from COL6A3 exon 6 with high copy numbers per cell identified by Immatics’ proprietary mass spectrometry platform, XPRESIDENT.
Over 90 different wild-type TCRs to this peptide were systematically evaluated using Immatics’ platform, XCEPTOR. After TCR characterization, engineering and validation, two affinity-enhanced TCR candidates were selected.
Both TCR candidates demonstrated promising preclinical properties including high avidity (sub-nanomolar EC50) and specificity towards target-positive tumor cells based on XPRESIDENT-guided screening for off-target toxicity and cross-reactivity.
In additional preclinical studies done in close collaboration with Jim Riley, Professor of Microbiology at the University of Pennsylvania, both product candidates showed tumor eradication in vitro and in vivo at physiological target expression levels.
One of the two TCR candidates showed full CD8-independent target recognition and engaged both CD8+ and CD4+ T cells without the need for CD8 co-transduction. Based on recent studies Immatics believes that the additional activation of CD4+ T cells is potentially favorable for induction and maintenance of anti-tumor responses against solid cancers.
After completion of ongoing final evaluation of the target and both TCR candidates, Immatics expects to submit an Investigational New Drug (IND) application to the US Food and Drug Administration (FDA) for the IMA204 program in 2021.
Steffen Walter, Ph.D., Chief Technology Officer at Immatics, commented: "Solid tumors develop a complex microenvironment where the tumor stroma plays a crucial role in tumor initiation, progression and metastasis by providing a protective defense layer against the body’s immune system. Taking apart the tumor’s defense network with novel and highly potent TCRs directed against the tumor stroma presents a promising opportunity to address hard to treat solid cancers."

About Immatics’ IMA204 Program
Immatics’ fourth ACTengine IMA204 program targets the tumor stroma and is designed to disrupt the tumor microenvironment. The rigid stroma and the immunosuppressive microenvironment of solid tumors pose a significant challenge for T cell accessibility and activity and targeting this compartment could provide a novel approach for many solid tumors. Immatics has selected two product candidates for its IMA204 program following the initial discovery of a novel stroma-associated peptide-HLA complex target using Immatics’ proprietary XPRESIDENT platform and the design of the right affinity-enhanced TCRs using its XCEPTOR platform. The target is present in high copy numbers in the tumor stroma and is part of the COL6A3 exon 6 protein, an extracellular matrix component that is expressed predominantly by tumor stroma cells but to a far lower extent in a few healthy tissues.

About Immatics’ ACT Programs
Immatics’ clinical product class ACTengine is a personalized approach for patients with advanced solid cancers. The patient’s own T cells are genetically modified to express a novel proprietary TCR against the cancer target that is then infused back into the patient. ACTengine programs IMA201, IMA202 and IMA203 are already in clinical studies for solid tumor indications, both in the US and in Germany. Immatics’ latest proprietary ACTengine manufacturing processes are designed to generate cell product candidates within a six day manufacturing window and to deliver highly proliferative T cells, with the capability to infiltrate the patient’s tumor and function in a challenging solid tumor microenvironment. The process is designed to rapidly produce younger, better-persisting T cells capable of "serial" killing tumor cells in vitro. Immatics is further advancing the ACT concept beyond individualized manufacturing with its product class ACTallo which is being developed to generate "off-the-shelf" cellular therapies.