1stOncology™: Cancer Intelligence Service – Page 11294 – 1stOncology is recognized as a Top 10 Global Pharma Analytic Provider

MacroGenics Enters Research Collaboration with Janssen to Develop Novel DART® Molecule

On December 18, 2020 MacroGenics, Inc. (NASDAQ: MGNX), a biopharmaceutical company focused on developing and commercializing innovative monoclonal antibody-based therapeutics for the treatment of cancer, reported a research collaboration and global license agreement to develop a preclinical bispecific molecule with Janssen Biotech, Inc (Press release, MacroGenics, DEC 18, 2020, View Source [SID1234573039]). The research collaboration will incorporate MacroGenics’ proprietary DART platform to enable simultaneous targeting of two undisclosed targets in a therapeutic area outside oncology.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

Schedule Your 30 min Free Demo!

"We are excited to collaborate with Janssen, which we believe is a leader in the field of next generation antibody-based therapeutics, by bringing together our two companies’ respective scientific talent and experience to leverage our DART platform to generate a compelling product candidate that addresses unmet patient needs," said Scott Koenig, M.D., Ph.D., President and Chief Executive Officer of MacroGenics.

Under the terms of the agreement, Janssen will pay MacroGenics an upfront payment of $20 million and will be responsible for funding all expenses. MacroGenics will also be eligible to receive up to $312 million in potential milestone payments and tiered royalties on worldwide product sales. Further details about the transaction are not disclosed.

Greenwich LifeSciences, Inc. Prices $26.4 Million Upsized Public Offering of Common Stock

On December 18, 2020 Greenwich LifeSciences, Inc. (Nasdaq: GLSI) (the "Company"), a clinical-stage biopharmaceutical company focused on the development of GP2, an immunotherapy to prevent breast cancer recurrences in patients who have previously undergone surgery, reported the pricing of an upsized underwritten public offering with gross proceeds to the Company expected to be approximately $26.4 million before deducting underwriting discounts and commissions and other estimated offering expenses payable by the Company (Press release, Greenwich LifeSciences, DEC 18, 2020, View Source [SID1234573038]).

The public offering equates to 660,000 shares of the Company’s common stock at a price of $40.00 per share. The Company intends to use the net proceeds for completion of all manufacturing and all clinical trial activities to complete an interim analysis and data readout of the GP2 Phase III clinical trial, for the submission of a Biologics Licensing Application to the FDA seeking conditional marketing approval of GP2, for the in-licensing or acquisition and development of additional products, including the coronavirus vaccine program, and for working capital and general corporate purposes.

The Company has also granted the underwriters a 45-day option to purchase up to an additional 99,000 shares of common stock offered in the public offering to cover over-allotments, if any, at the public offering price, which would increase the total gross proceeds of the offering to approximately $30.4 million, if exercised in full. The offering is expected to close on or about December 22, 2020, subject to customary closing conditions.

Aegis Capital Corp. is acting as sole bookrunner for the offering.

A registration statement relating to the shares of common stock being sold in this offering was declared effective by the Securities and Exchange Commission (the "SEC") on December 17, 2020. The offering is being made only by means of a prospectus. Copies of the final prospectus may be obtained, when available, on the SEC’s website, www.sec.gov, or by contacting Aegis Capital Corp., Attention: Syndicate Department, 810 7th Avenue, 18th Floor, New York, NY 10019, by email at [email protected], or by telephone at (212) 813-1010.

This press release shall not constitute an offer to sell, or a solicitation of an offer to buy these securities, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Mersana Therapeutics to Host Virtual Analyst and Investor Event

On December 17, 2020 Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, reported that it will host a virtual Analyst and Investor event on Tuesday, January 5, 2021 from 10:00 a.m. to 12:00 p.m. ET (Press release, Mersana Therapeutics, DEC 17, 2020, View Source [SID1234575006]). The event will showcase the following agenda:

Debra L. Richardson, MD, Associate Professor and Section Chief, Division of Gynecologic Oncology at the OU Health Stephenson Cancer Center and the Sarah Cannon Research Institute, will review updated data from the ovarian cancer cohort of the Phase 1 expansion study evaluating XMT-1536, the Company’s first-in-class ADC candidate targeting NaPi2b.
Mersana’s management team will detail the Company’s plans for the registration-enabling study of XMT-1536 in platinum-resistant ovarian cancer and outline its objectives for longer-term life cycle management studies to evaluate the potential of XMT-1536 in platinum-sensitive ovarian cancer.
Mersana’s management team will disclose preclinical data supporting the development of the Company’s first-in-class B7-H4 DolaLock ADC development candidate.
Mersana’s management team will outline the Company’s anticipated 2021 goals and milestones for its clinical and early-stage ADC programs.
Webcast and Conference Call Details
A live webcast of the presentation will be available on the Investors & Media section of the Mersana website at View Source Analyst and Investors may ask a question during the live Q&A by dialing (855) 940-5308 (toll-free domestic) or (929) 517-9745 (international) and providing the Conference ID 6265117.

Perrigo to Present Virtually at Upcoming Investor Conferences

On December 17, 2020 Perrigo Company plc (NYSE; TASE: PRGO), reported that EVP and President of Consumer Self-Care Americas, Rich Sorota will present at the ICR Conference at 11:30 AM EST on Monday, January 11, 2021 (Press release, Perrigo Company, DEC 17, 2020, View Source [SID1234573012]).

Perrigo President & CEO Murray S. Kessler and CFO, Ray Silcock, will present at the 39th Annual J.P. Morgan Global Healthcare Conference at 3:40 PM EST on Wednesday, January 13, 2021. Interested parties can access the presentation webcasts at View Source

Allterum Therapeutics completes Series Seed offering, builds team with addition of Philip Breitfeld as Chief Medical Officer

On December 17, 2020 Allterum Therapeutics, Inc. reported that it completed its $1.8 million Series Seed offering to members of the FanninDirectSM investor group (Press release, Allterum, DEC 17, 2020, View Source [SID1234573011]). Allterum is developing a novel immunotherapy for treatment of IL7R-expressing cancers, including difficult to treat cases of pediatric acute lymphoblastic leukemia (ALL), a program which has received both Orphan Drug and Rare Pediatric Disease Designations from FDA. The company will use the proceeds for its pre-clinical antibody manufacturing and toxicology work and to continue to build the management team.

Philip P. Breitfeld, MD, a pediatric oncologist and former Global Vice President, Therapeutic Centers of Excellence of IQVIA (the renamed Quintiles/IMS Health), has joined Allterum as Chief Medical Officer. Dr. Breitfeld has over thirty five years experience in clinical development, including at major pharmaceutical and biotechnology companies.

"Having been fortunate to be part of the care of many children and adolescents with ALL, it is a dream to be part of the Allterum team focused on bringing new therapeutic options to children with ALL," said Dr. Breitfeld.

Although a majority of pediatric patients with ALL are successfully treated with current chemotherapies, a subset of patients experience relapse. In particular, patients with recurring T-cell ALL have extremely limited therapeutic options; as a result, these patients frequently have a poor prognosis. Allterum’s immunotherapy, invented at the National Cancer Institute by Dr. Scott Durum and his colleagues, was designed to be effective in these patients. It is also expected to benefit a much larger group of patients with IL7-R-expressing cancers including additional patients with leukemias, as well as sub-populations of patients with solid tumors.

"We are delighted to welcome Dr. Breitfeld to the team," said Dr. Atul Varadhachary, Allterum President & CEO. "He will play a pivotal role in advancing our programs addressing unmet critical medical needs in both childhood leukemias and in solid tumors."

Allterum is partnering with the Therapeutics Advances in Childhood Leukemia & Lymphoma (TACL) consortium to design a Phase 1/2 clinical trial, with Dr. Eric Schafer (Baylor College of Medicine and Texas Children’s Hospital) and Dr. Susan Rheingold (Children’s Hospital of Philadelphia) as Chair and Vice-Chair, respectively, of the study. Allterum anticipates filing an Investigational New Drug (IND) application to the FDA in early 2021, leading to the launch of the clinical trial.

In addition to the initial sponsor funding by Fannin Partners and the Series Seed proceeds, Allterum has also received a $2.9 million Product Development grant from the Cancer Prevention Research Institute of Texas (CPRIT).