SenesTech to Report First Quarter 2020 Financial Results on Friday, May 15, 2020

On May 12, 2020 SenesTech, Inc. (NASDAQ: SNES), a developer of proprietary technologies for managing animal pest populations through fertility control, reported that it will report financial results for its first quarter 2020, ended March 31, 2020, before the market open on Friday, May 15, 2020 (Press release, SenesTech, MAY 12, 2020, View Source [SID1234557622]). The Company has scheduled a conference call that same day, Friday, May 15, 2020, at 11:00 am ET, to review the results.

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First Quarter 2020 Conference Call Details

Date and Time: Friday, May 15, 2020 at 11:00 am ET

Call-in Information: Interested parties can access the conference call by dialing (844) 308-3351 or (412) 317-5407.

Live Webcast Information: Interested parties can access the conference call via a live Internet webcast, which is available in the Investor Relations section of the Company’s website at View Source." target="_blank" title="View Source." rel="nofollow">View Source

Replay: A teleconference replay of the call will be available for three days at (877) 344-7529 or (412) 317-0088, confirmation #10144162. A webcast replay will be available in the Investor Relations section of the Company’s website at View Source for 90 days.

Medicure Reports Financial Results for Quarter Ended March 31, 2020

On May 12, 2020 Medicure Inc. ("Medicure" or the "Company") (TSXV:MPH, OTC:MCUJF), a cardiovascular pharmaceutical company, reported its results from operations for the quarter ended March 31, 2020 (Press release, Medicure, MAY 12, 2020, View Source [SID1234557621]).

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Quarter Ended March 31, 2020 Highlights:

Recorded total net revenue from the sale of products of $3.0 million during the quarter ended March 31, 2020 compared to $4.9 million for the quarter ended March 31, 2019;

Recorded total net revenue from the sale of AGGRASTAT of $2.7 million during the quarter ended March 31, 2020 compared to $4.8 million for the quarter ended March 31, 2019;

Adjusted earnings before interest, taxes, depreciation and amortization (EBITDA1) for the quarter ended March 31, 2020 was negative $1.3 million compared to adjusted EBITDA of negative $1.7 million for the quarter ended March 31, 2019; and

Net loss for the quarter ended March 31, 2020 was $1.5 million compared to net loss of $2.8 million for the quarter ended March 31, 2019.
Financial Results

Net revenues for the three months ended March 31, 2020 were $3.0 million compared to $4.9 million for the three months ended March 31, 2019. Net revenues from AGGRASTAT for the three months ended March 31, 2020 were $2.7 million compared to $4.8 million for the three months ended March 31, 2019. ZYPITAMAGTM and SNP contributed $163,000 and $31,000, respectively during the three months ended March 31, 2020. Additionally, ReDSTM contributed net revenue of $89,000 for the three months ended March 31, 2020 compared to $103,000 for the three months ended March 31, 2019.

The Company continues to show strong patient market share with AGGRASTAT, however, the market share is offset by increased price competition caused by enhanced generic Integrilin competition, which resulted in lower discounted prices for AGGRASTAT into the first quarter of 2020. There was also decreases in the volume of the product sold compared to 2019. The Company is beginning to see an increase in demand for ZYPITAMAGTM and expects growth in ZYPITAMAGTM revenues going forward.

Adjusted EBITDA for the three months ended March 31, 2020 was negative $1.3 million compared to negative $1.7 million for the three months ended March 31, 2019. The change in adjusted EBITDA for the three months ended March 31, 2020 is the result of lower selling, general and administration and research and development expenses, partially offset by lower revenues during the three months ended March 31, 2020 when compared to the same period in 2019.

Net loss for the three months ended March 31, 2020 was $1.5 million or $0.14 per share compared to net loss of $2.8 million or $0.18 per share for the three months ended March 31, 2019. The change in the net loss for the three months ended March 31, 2020 is the result of lower selling, general and administration and research and development expenses and a gain on foreign exchange, partially offset by lower revenues experienced during the three months ended March 31, 2020 when compared to the three months ended March 31, 2019.

At March 31, 2020, the Company had unrestricted cash totaling $12.7 million consistent with the $13.0 million of unrestricted cash held as of December 31, 2019. Cash flows used in operating activities for the three months ended March 31, 2020 totaled $822,000 compared to $1.9 million for the three months ended March 31, 2019.

All amounts referenced herein are in Canadian dollars unless otherwise noted.

Notes

(1) The Company defines EBITDA as "earnings before interest, taxes, depreciation, amortization and other income or expense" and Adjusted EBITDA as "EBITDA adjusted for non‑cash and non-recurring items". The terms "EBITDA" and "Adjusted EBITDA", as it relates to the three months ended March 31, 2020 and 2019 results prepared using IFRS, do not have any standardized meaning according to IFRS. It is therefore unlikely to be comparable to similar measures presented by other companies.

Conference Call Info:

Webcast: This conference call will be webcast live over the internet and can be accessed from the Medicure investor relations page at the following link: View Source

You may request international country-specific access information by e-mailing the Company in advance. Management will accept and answer questions related to the financial results and operations during the question-and-answer period at the end of the conference call. A recording of the call will be available following the event at the Company’s website.

Frazier Healthcare Partners Launches Lengo Therapeutics

On May 12, 2020 Frazier Healthcare Partners ("Frazier") reported the launch of Lengo Therapeutics, Inc. ("Lengo"), a biopharmaceutical company focused on the discovery and development of novel treatments targeting driver mutations in oncology (Press release, Frazier Healthcare, MAY 12, 2020, View Source [SID1234557620]).

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"Lengo emerged from discussions at Frazier and among a highly experienced group of oncology researchers, including Frazier Senior Advisors Roger Ulrich, Ph.D., Jim Bristol, Ph.D., Michael Gallatin, Ph.D. and Bruce Roth, Ph.D., who helped identify several mutations in cancers that we felt were not well addressed by existing therapeutics," said Tracy Saxton, Ph.D., CEO of Lengo. "We were fortunate to identify novel chemical matter discovered at Jubilant to address some of these mutations of interest."

Jubilant Life Sciences Ltd ("Jubilant") has granted an exclusive license to Lengo for the worldwide development and commercialization of a portfolio of novel chemistry against undisclosed oncology targets. In connection with the license, Lengo has completed a $15 million Series A financing round from Frazier.

Jubilant and Frazier have been working together on multiple discovery-stage companies since 2016, starting with Mavupharma which was acquired by AbbVie in 2019.

"Company formation is one of our core activities at Frazier, and Jubilant has been a key part of several of our early-stage companies," said Daniel Estes, Ph.D., General Partner on the Frazier Life Sciences team. "We are excited to advance the assets we have licensed at Lengo to the clinic as quickly as possible."

"We are pleased to be strengthening our ties with Frazier Healthcare Partners," said Shyam Bhartia and Hari Bhartia, founders of Jubilant. "We welcome the addition of Lengo to the pipeline of companies we are working on together in drug discovery."

Eagle Pharmaceuticals to Present at the 2020 RBC Capital Markets Global Healthcare Virtual Conference

On May 12, 2020 Eagle Pharmaceuticals, Inc. (Nasdaq: EGRX) ("Eagle" or the "Company") reported that Scott Tarriff, Chief Executive Officer, and Pete Meyers, Chief Financial Officer, will host a fireside chat at the 2020 RBC Capital Markets Global Healthcare Virtual Conference as follows (Press release, Eagle Pharmaceuticals, MAY 12, 2020, View Source [SID1234557619]):

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Date: Tuesday, May 19, 2020
Time: 3:05 p.m. Eastern Time
Webcast: https://www.veracast.com/webcasts/rbc/healthcare2020/01112239705.cfm
The presentation will be webcast live at the aforementioned time, and archived for 30 days thereafter, via the Company’s website at www.eagleus.com, under the Investors section.

Legend Biotech and Noile-Immune Biotech Announce Collaborative Research and Licensing Agreement

On May 12, 2020 Legend Biotech Corporation ("Legend"), a global clinical stage biopharmaceutical company engaged in the discovery and development of novel cell therapies, reported that Legend and Noile-Immune Biotech, Inc. ("Noile-Immune"), a biotechnology company focusing on the development of innovative cancer immunotherapies, have entered into a license agreement whereby Legend will have the right to develop CAR-T and/or TCR-T cell therapies incorporating Noile-Immune’s PRIME (proliferation-inducing and migration-enhancing) technology secreting both IL-7 and CCL19 (Press release, Legend Biotech, MAY 12, 2020, View Source [SID1234557618]). The PRIME technology is designed to improve proliferation and trafficking into solid tumors of both engineered CAR-T and/or TCR-T cells, as well as the patient’s own T cells.

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"We are pleased to enter this strategic collaboration with Noile-Immune Biotech, allowing us to bring together our growing portfolio of solid tumor pipeline programs with Noile-Immune’s PRIME technology," said Dr. Frank Fan, Chief Scientific Officer and Co-founder of Legend Biotech. "Utilizing Noile-Immune’s innovative technology platform, we aim to bolster Legend’s novel CAR-T/TCR-T platforms to develop cutting-edge therapeutic candidates in our mission to deliver highly impactful treatments to patients living with cancer."

"As cell therapies evolve to include solid tumors, it becomes clear that improving CAR-T cell trafficking to tumor sites is important for potent tumor cell killing" said Dr. Yuan Xu, Chief Executive Officer and Board Member of Legend Biotech. "This collaboration demonstrates our commitment to invest in highly innovative technologies as we seek to deliver therapies that address the needs of patients with solid tumor cancers."

"It is a great advancement to establish a strategic collaboration with Legend Biotech, a clinical stage biopharmaceutical company that has shown promise in the development of gene-modified T cell therapies," said Dr. Koji Tamada, Scientific Founder and External Director of Noile-Immune Biotech. "From a scientific perspective, with the combination of our PRIME technology and the innovative programs of Legend Biotech, our goal is to generate effective therapeutic candidates for the treatment of various solid tumor types that may yield a novel benchmark for immunotherapy in cancer patients."

"This new partnership is one more confirmation of the interest of global CAR-T experts for our PRIME technology," said Dr. Hidenobu Ishizaki, Chief Executive Officer and Co-Founder of Noile-Immune Biotech. "This collaboration will be invaluable in our efforts to accelerate the development of innovative cellular immunotherapy. We look forward to working with the Legend Biotech team and bringing potentially breakthrough cancer therapies to patients."

Under the multi-year collaboration agreement, Legend and Noile-Immune will work together on up to two select cancer targets. Legend will gain the right to incorporate the PRIME technology into its CAR-T and/or TCR-T cell programs and will provide to Noile-Immune a total of up to $70M per selected target for certain development, regulatory and commercial milestone payments. Noile-Immune will also be entitled to receive mid-single digit royalties on net sales of any resulting products.