Achilles Therapeutics to present at Jefferies Virtual Healthcare Conference

On May 28, 2020 Achilles Therapeutics ("Achilles"), a clinical-stage oncology company developing personalised cell therapies targeting clonal neoantigens, a novel class of tumour target, reported that Iraj Ali, Chief Executive Officer, will present at the Jefferies Virtual Healthcare Conference on Tuesday, June 2, 2020, at 9:00 a.m. Eastern Time (Press release, Achilles Therapeutics, MAY 28, 2020, View Source [SID1234558595]).

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Turning Point Therapeutics Announces Full Exercise of Underwriters’ Option to Purchase Additional Shares in Public Offering of Common Stock

On May 27, 2020 Turning Point Therapeutics, Inc. (Nasdaq: TPTX), a precision oncology company developing next-generation therapies that target genetic drivers of cancer, reported that the underwriters of its previously announced underwritten public offering of its common stock have exercised in full their option to purchase 812,500 additional shares of common stock at the public offering price of $60.00 per share (Press release, Turning Point Therapeutics, MAY 27, 2020, View Source [SID1234564372]). The initial sale of 5,416,667 shares of common stock was completed on May 21, 2020 and the sale of the additional 812,500 shares is expected to close on or about May 28, 2020, subject to satisfaction of customary closing conditions. The total gross proceeds to Turning Point from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Turning Point, are expected to be approximately $373.8 million.

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Goldman Sachs & Co. LLC, SVB Leerink and Guggenheim Securities are acting as joint bookrunning managers for the offering. Wedbush PacGrow is acting as lead manager and H.C. Wainwright & Co. is acting as co-manager for the offering.

The shares of common stock described above are being offered by Turning Point pursuant to a shelf registration statement on Form S-3, including a base prospectus, that was previously filed with and became effective by rule of the Securities and Exchange Commission (the "SEC") on May 15, 2020. A final prospectus supplement and accompanying prospectus relating to the offering were filed with the SEC and are available on the SEC’s website located at View Source Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may be obtained from: Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, New York 10282, via telephone: 1-866-471-2526, or via email: [email protected]; SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at 1-800-808-7525, ext. 6218 or by email at [email protected]; or Guggenheim Securities, LLC Attention: Equity Syndicate Department, 330 Madison Avenue, New York, NY 10017 or by telephone at 212-518-5548, or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

ORIC Pharmaceuticals Announces Five Presentations at the 2020 American Association for Cancer Research Virtual Annual Meeting II

On May 27, 2020 ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, reported that multiple poster presentations highlighting preclinical data from the company’s glucocorticoid receptor (GR) antagonist and CD73 inhibitor programs will be presented at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting II being held June 22-24, 2020 (Press release, ORIC Pharmaceuticals, MAY 27, 2020, View Source [SID1234561056]).

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Details of the planned presentations are as follows:

ORIC-101 (GR Antagonist) Poster Presentations:
Title: ORIC-101 comprehensively inhibits glucocorticoid pathways to overcome therapeutic resistance in pan-cancer models
Date: June 22, 2020
Session: Mechanisms of Sensitivity and Resistance to Targeting Hormone Responsive Cancer
Abstract: 4120

Title: ORIC-101 overcomes resistance to diverse chemotherapeutics across cancer types
Date: June 22, 2020
Session: Mechanisms of Sensitivity and Resistance to Targeting Hormone Responsive Cancer
Abstract: 4121

Title: ORIC-101 overcomes glucocorticoid receptor-mediated chemoresistance in pancreatic cancer models
Date: June 22, 2020
Session: Mechanisms of Sensitivity and Resistance to Targeting Hormone Responsive Cancer
Abstract: 4123

ORIC-533 (CD73 Inhibitor) Poster Presentations:
Title: CD73 inhibition with a novel orally bioavailable small molecule blocks adenosine production and rescues T-cells activation
Date: June 22, 2020
Session: Tumor Induced Immune Suppression
Abstract: 1023

Title: An orally bioavailable inhibitor of CD73 reverts intratumoral immunosuppression and promotes anti-tumor responses
Date: June 22, 2020
Session: Late-Breaking Research: Experimental and Molecular Therapeutics 2
Abstract: LB-115

Blueprint Medicines to Present at Upcoming Investors Conferences

On May 27, 2020 Blueprint Medicines Corporation (NASDAQ:BPMC), a precision therapy company focused on genomically defined cancers, rare diseases and cancer immunotherapy, reported its participation in the following upcoming investor conferences (Press release, Blueprint Medicines, MAY 27, 2020, View Source [SID1234558628]):

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Jefferies Virtual Global Healthcare Conference on Wednesday, June 3, 2020 at 10:30 a.m. ET.
Virtual Goldman Sachs 41st Annual Global Healthcare Conference on Wednesday, June 10, 2020 at 8:50 a.m. ET.
JMP Securities Virtual Hematology and Oncology Forumon Thursday, June 18, 2020 at 10:00 a.m. ET.
A live webcast of each presentation will be available by visiting the Investors & Media section of Blueprint Medicines’ website at View Source A replay of the webcasts will be archived on Blueprint Medicines’ website for 30 days following each presentation.

Iovance Biotherapeutics, Inc. Announces Proposed Public Offering of Common Stock

On May 27, 2020 Iovance Biotherapeutics, Inc. (Nasdaq: IOVA) ("Iovance" or "Company"), a late-stage biotechnology company developing novel T cell-based cancer immunotherapies (tumor-infiltrating lymphocyte, TIL and peripheral-blood lymphocyte, PBL), reported that it intends to offer and sell $500 million of its common stock, subject to market and other conditions, in an underwritten public offering (Press release, Iovance Biotherapeutics, MAY 27, 2020, View Source [SID1234558627]). All of the shares in the offering are to be sold by Iovance. Iovance intends to grant the underwriters a 30-day option to purchase up to $75 million of additional shares of common stock at the public offering price, less the underwriting discounts and commissions.

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Iovance intends to use the proceeds from this offering to fund the expansion of its organization to support the potential commercial launch of lifileucel for advanced melanoma and LN-145 for advanced cervical cancer, to initiate a program directed at registration of Iovance’s tumor infiltrating lymphocyte therapies in non-small cell lung cancer, to continue support of ongoing commercial manufacturing activities, and for the development of Iovance’s IL-2 analog, IOV-3001, and for other general corporate purposes. Additional indications or TIL products may be explored with the use of proceeds.

Jefferies LLC and Goldman Sachs & Co. LLC are acting as joint lead book-running managers for the offering. Wells Fargo Securities, LLC is also serving as book-running manager.

The shares of common stock described above are being offered by Iovance pursuant to its shelf registration statement on Form S-3 that became automatically effective upon filing with the Securities and Exchange Commission (the "SEC") on May 27, 2020. The offering may be made only by means of a prospectus supplement and accompanying prospectus, copies of which may be obtained by contacting Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor New York, New York, 10022, by telephone at (877) 547-6340, or by email at [email protected] or Goldman Sachs & Co. LLC by mail at 200 West Street, New York, NY 10282, Attention: Prospectus Department, by telephone at (866) 471-2526, or by email at [email protected] or Wells Fargo Securities, LLC, Attention: Equity Syndicate Department, 500 West 33rd Street, New York, New York, 10001, at (800) 326-5897 or email a request to [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.