Lineage Cell Therapeutics to Present at 2020 Solebury Trout Virtual Investor Conference on May 26, 2020

On May 18, 2020 Lineage Cell Therapeutics, Inc. (NYSE American and TASE: LCTX), a clinical-stage biotechnology company developing novel cell therapies for unmet medical needs, reported that Brian M. Culley, Chief Executive Officer, will be presenting at the 2020 Solebury Trout Virtual Investor Conference on May 26, 2020 at 2:30 pm Eastern Time (Press release, Lineage Cell Therapeutics, MAY 18, 2020, View Source [SID1234558225]). Interested investors can access the live presentation as part of the Solebury Trout Virtual Conference Series.

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The archived presentation will be posted on the Events and Presentations section of Lineage’s website the day following the event and will be available for 30 days. Additional videos are available on the Media page of the Lineage website, located at www.lineagecell.com/media/.

VBL Therapeutics to Present New Data on Its MOSPD2 Bispecific Antibody Program for Solid Tumors in Late Breaking Research Session of the AACR Virtual Annual Meeting

On May 18, 2020 VBL Therapeutics (Nasdaq: VBLT) reported that new data suggesting the potential of its proprietary bi-specific antibodies for immune-mediated targeting of solid tumors will be presented at the Annual American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting II, to be held June 22–24, 2020 (Press release, VBL Therapeutics, MAY 18, 2020, View Source [SID1234558223]). VBL’s data show that MOSPD2 bi-specific antibodies induce T-cell activation and significantly extend the survival of mice carrying established metastatic cervical cancer, with no evidence of toxicity.

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VBL’s research has identified MOSPD2 as a protein involved in cell motility, whose expression is highly elevated in various solid tumors. The proprietary bi-specific antibodies developed by VBL have two separate arms – one arm binds to MOSPD2 on tumor cells and the second recruits host T-cells that attack the tumor. The new data to be presented at AACR (Free AACR Whitepaper) highlight the potential of bi-specific mediated immuno-oncology investigational therapy for the treatment of various MOSPD2-expressing solid tumors.

Details for the AACR (Free AACR Whitepaper) 2020 Virtual Meeting II presentations are as follows :

Permanent Abstract Number: LB-086
Title: CD3 MOSPD2 bi-specific antibody significantly prolongs survival in a model of metastatic human cervical cancer without any evidence of toxicity
Authors: Yacov et al.
Session Type: Poster Session
Session Category: Immunology
Session Title: Late-Breaking Research: Immunology 1

Permanent Abstract Number: 5592
Title: MOSPD2 a novel target for bi-specific antibody mediated solid tumor cells immune death
Authors: Salem et al.
Session Type: Poster Session
Session Category: Immunology
Session Title: Inflammation, Immunity, and Cancer / Modifiers of the Tumor Microenvironment 2
VBL’s presentations will be available on the AACR (Free AACR Whitepaper) e-poster website on June 22, 2020.

About VBL’s VB-600 Platform
VBL is conducting two parallel drug development programs that are exploring the potential of MOSPD2 (motile sperm domain-containing protein 2), a protein that VBL has identified as a key regulator of cell motility, as a therapeutic target for inflammatory diseases and cancer. Our VB-600 platform comprises classical anti-MOSPD2 investigational monoclonal antibodies for inflammatory indications, as well as bi-specific antibody candidates for oncology.

NuCana Announces the Re-Opening of Enrollment in Multiple Clinical Studies
After Temporary Pause Due to COVID-19 Pandemic

On May 18, 2020 NuCana plc (NASDAQ: NCNA) reported it has re-commenced enrollment of new patients in multiple clinical studies following the temporary pause necessitated by the COVID-19 pandemic (Press release, Nucana BioPharmaceuticals, MAY 18, 2020, View Source [SID1234558222]). NuCana previously announced the re-opening of its global Phase III study of Acelarin plus cisplatin in patients with biliary tract cancer (NuTide:121) on May 5, 2020. NuCana has now also re-opened the Phase I and Phase Ib clinical studies of NUC-3373 and the Phase I clinical study of NUC-7738.

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"All of our clinical studies have now re-opened to new patient enrollment and we are pleased to be treating once again new patients who may benefit from our ProTides" said Hugh S. Griffith, NuCana’s Founder and Chief Executive Officer. "The COVID-19 pandemic has had a dramatic impact on the global healthcare delivery system and advancing clinical studies of potential new treatments for cancer patients is of critical importance to NuCana."

The following clinical studies have re-opened to new-patient enrollment:

NuTide:121, the Phase III study of Acelarin (NUC-1031) plus cisplatin in patients with biliary tract cancer. The re-opening of NuTide:121 has begun in certain geographies including Australia, Canada, South Korea, Taiwan, Ukraine and the United Kingdom.

NuTide:302, the Phase Ib study of NUC-3373 in combination with other agents typically combined with 5-fluorouacil (5-FU) in patients with advanced colorectal cancer. The re-opening of NuTide:302 has begun in the United Kingdom.

NuTide:301, the Phase I clinical study of NUC-3373 in patients with advanced solid tumors.

NuTide:701, the Phase I clinical study of NUC-7738 in patients with advanced solid tumors.

bluebird bio Announces Proposed Public Offering of Common Stock

On May 18, 2020 bluebird bio, Inc. (Nasdaq: BLUE) reported that it has commenced an underwritten public offering of $400 million of its common stock (Press release, bluebird bio, MAY 18, 2020, View Source [SID1234558221]). bluebird bio also intends to grant the underwriters a 30-day option to purchase up to an additional fifteen percent (15%) of the shares of common stock offered in the public offering. All of the shares in the proposed offering are to be sold by bluebird bio.

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Goldman Sachs & Co. LLC, BofA Securities and Cowen are acting as joint book-running managers of the proposed offering. The offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

The shares are being offered by bluebird bio pursuant to an automatically effective shelf registration statement that was previously filed with the Securities and Exchange Commission (SEC). A preliminary prospectus supplement relating to and describing the terms of the offering will be filed with the SEC and will be available on the SEC’s website at www.sec.gov. When available, copies of the preliminary prospectus supplement and the accompanying prospectus relating to these securities may also be obtained by contacting one of the following: Goldman Sachs & Co. LLC, Attn: Prospectus Department, 200 West Street, New York, NY 10282, telephone: (866) 471-2526, facsimile: (212) 902-9316, email: [email protected]; BofA Securities, NC1-004-03-43, 200 North College Street, 3rd floor, Charlotte, NC 28255-0001, Attn: Prospectus Department, or via email: [email protected]; and Cowen and Company, LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, New York 11717, Attn: Prospectus Department, by telephone at (833) 297-2926, or by email at [email protected]. The final terms of the offering will be disclosed in a final prospectus supplement to be filed with the SEC.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such state or jurisdiction.

Corporate Presentation

On May 18, 2020 INmune Bio presented a corporate presentation (Presentation, INmune Bio, MAY 18, 2020, View Source [SID1234558217]).

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