Sagimet Biosciences Announces Pricing of $175.0 Million Underwritten Offering of Series A Common Stock

On April 27, 2026 Sagimet Biosciences Inc. (Nasdaq: SGMT), a clinical-stage biopharmaceutical company developing novel therapeutics targeting dysfunctional metabolic and fibrotic pathways, reported the pricing of an underwritten offering of 29,166,700 shares of its Series A common stock at a price of $6.00 per share. The gross proceeds from the offering are expected to be approximately $175.0 million, before deducting underwriting discounts and commissions and other offering expenses. All of the shares in the offering are to be sold by Sagimet. The offering is expected to close on or about April 28, 2026, subject to the satisfaction of customary closing conditions.

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The financing included participation from new and existing investors, including Balyasny Asset Management, Blue Owl Healthcare Opportunities, BVF Partners L.P., Caligan Partners, Coastlands Capital, Farallon Capital Management, Great Point Partners, LLC, Woodline Partners LP and a Large Mutual Fund.

Leerink Partners, TD Cowen, Guggenheim Securities and Oppenheimer & Co. are acting as joint bookrunning managers for the offering. Canaccord Genuity, H.C. Wainwright & Co. and Jones are acting as co-lead managers for the offering.

Sagimet intends to use the net proceeds from the offering, together with its existing cash, cash equivalents and marketable securities, to fund a Phase 3 clinical trial for denifanstat in acne, fund TVB-3567 through Phase 2 topline results, advance a topical formulation FASN inhibitor to IND submission and for general corporate purposes, including additional clinical development, working capital and operating expenses. The Company currently expects that its existing cash and cash equivalents, together with the proceeds from the offering, will fund its acne programs through 2028 and the readout of the Company’s planned denifanstat Phase 3 clinical trial in moderate to severe acne.

A shelf registration statement on Form S-3 (File No. 333-281582) relating to these shares was filed with the Securities and Exchange Commission (the "SEC") and declared effective on August 26, 2024. A prospectus supplement relating to the offering, and the accompanying prospectus, will be filed with the SEC. When available, copies of the prospectus supplement and accompanying prospectus may also be obtained from the offices of Leerink Partners LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, by telephone at (800) 808-7525, ext. 6105, or by email at [email protected]; TD Securities (USA) LLC, Attention: Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717 or by email at [email protected]; or Guggenheim Securities, LLC, Attention: Equity Syndicate Department, 330 Madison Avenue, 8th Floor, New York, NY 10017, by telephone at (212) 518-9544, or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these shares, nor will there be any sale of these shares in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state, province, territory or other jurisdiction.

(Press release, Sagimet Biosciences, APR 27, 2026, View Source [SID1234664836])

BriaCell Announces Six Clinical Data Presentations at ASCO 2026

On April 27, 2026 BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) ("BriaCell" or the "Company"), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, reported three clinical data poster presentations and three publication-only abstracts at the 2026 ASCO (Free ASCO Whitepaper) Annual Meeting, taking place May 29-June 2, 2026 at McCormick Place, Chicago, Illinois. The details of the poster presentation sessions and publish-only abstracts are listed below.

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Abstract Title: Survival with Bria-IMT + CPI in advanced metastatic breast cancer at 12 and 24 months.
Session Type/Title: Poster Session – Breast Cancer—Metastatic
Poster Board: 222
Date and Time: June 1, 2026, 1:30 PM-4:30 PM CDT

Abstract Title: Quality of life and treatment tolerability of Bria-IMT + CPI in metastatic breast cancer.
Session Type/Title: Poster Session – Breast Cancer—Metastatic
Poster Board: 221
Date and Time: June 1, 2026, 1:30 PM-4:30 PM CDT

Abstract Title: Monitoring blood-based biomarkers as early predictors of progression-free survival in a randomized Bria-ABC phase 3 trial for advanced metastatic breast cancer: An ongoing analysis.
Session Type/Title: Poster Session – Developmental Therapeutics—Immunotherapy
Poster Board: 442
Date and Time: May 30, 2026, 1:30 PM-4:30 PM CDT

Publication-Only Abstract Title: Cell-based second-generation immunotherapy BC1 in metastatic breast cancer.

Publication-Only Abstract Title: Liquid biopsy to stratify metastatic breast cancer progression risk using multi-analyte cell subtyping prior to systemic therapy.

Publication-Only Abstract Title: Monitoring PD-L1 expression in circulating cancer associated cells for prediction of clinical outcomes in metastatic breast cancer patients treated with immune checkpoint inhibitors.

Presentation details will become available upon publication of the abstracts by ASCO (Free ASCO Whitepaper) on May 21, 2026 at 5:00 PM ET.

Following the presentation, copies of the posters will be made available at View Source

(Press release, BriaCell Therapeutics, APR 27, 2026, View Source [SID1234664835])

HCW Biologics Delivers a Major Update for its T-Cell Engager Program Revealing Mechanism of Action and Validating Tissue Factor as Target for Treatment of Solid Tumors

On April 27, 2026 HCW Biologics Inc. (the "Company" or "HCW Biologics"), (NASDAQ: HCWB), a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to support or treat diseases promoted by chronic inflammation reported major development regarding its tetra-valent, second-generation T-Cell Engager Program (the "Big BiTE") based on its TRBC platform technology, was presented at the poster session at the American Association of Cancer Research ("AACR") Annual Meeting 2026, which took place from April 17 – 22, 2026 in San Diego, California.

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HCW11-018b, the lead candidate of the "Big BiTE" program, is a tetra-valent T-cell engager designed to enhance anti-tumor activities and tolerability to treat a wide spectrum of solid tumors. The Company’s preclinical data showed HCW11-018b could significantly shrink well-established tumors and prevent cancer metastasis in xenograft animal models with broad coverage for human solid tumor indications.

The new data in the poster has revealed the mechanism of action that drives these results. HCW11-018b utilizes Cis-binding (or cis-interaction) to regulate immune cell reactivity that masks the receptors which prevent trans-binding and inhibit membrane flexibility. The data showed that HCW11-018b is only activated within the tumor microenvironment, which is expected to increase the efficacy and tolerability of this tetra-valent T Cell Engager against human tumor cells.

Dr. Hing C. Wong, the Company’s Founder and Chief Executive Officer, stated, "HCW11-018b exhibits remarkable anti-tumor activities with high tolerability in animal models. With its streamlined GMP manufacturing process, the Company is vigorously -pursuing the clinical development path for solid tumors with particular focus on pancreatic and ovarian cancer. The IND application is projected to be filed in the first half of 2027."

The poster, entitled, "An innovative approach to improve bispecific T-cell engagers for solid tumor therapy," was presented by Dr. Wong at the AACR (Free AACR Whitepaper) Annual Meeting 2026. The poster is available on the Company’s investors’ website in the following link: View Source

(Press release, HCW Biologics, APR 27, 2026, View Source [SID1234664834])

TScan Therapeutics Announces Upcoming Presentation at the American Society of Gene and Cell Therapy 29th Annual Meeting

On April 27, 2026 TScan Therapeutics, Inc. (Nasdaq: TCRX), a clinical-stage biotechnology company focused on the development of T cell receptor (TCR)-engineered T cell (TCR-T) therapies for the treatment of patients with cancer, reported the acceptance of an abstract for poster presentation at the upcoming American Society of Gene and Cell Therapy (ASGCT) (Free ASGCT Whitepaper) 29ᵗʰ Annual Meeting being held May 11 – 15 in Boston, MA as well as virtually.

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Poster Presentation Details:

Title: Novel CD45-targeted TCR-T cell therapies designed to eliminate residual disease and prevent relapse following allogeneic hematopoietic cell transplantation
Authors: Hannah L Bader, Kostadin P Petrov, Stephen Carroll, Debanjan Goswamy, Nivya Sharma, Shubhangi Kamalia, Daniel Pollacksmith, Drashti Sha, Kenneth L Jahan, Ryan E Kritzer, Hana Husic, Shobhita Jillella, Nicole Ladd, Jackson Lirette, Shoshana Bloom, Prachi Dhanania, Lisa Fleischer, Chandan K Pavuluri, Tyler M Sinacola, Savannah G Szemethy, McKenna A Merrill, Kyra N Sur, Carolyn Hardy, Zhonghua Zhu, Elisaveta Todorova, Alexander Cristofaro, Livio Dukaj, Kimberly M Cirelli, Antoine Boudot, Mollie M Jurewicz, Cagan Gurer
Abstract ID: 1256
Session Date/Time: Tuesday, May 12; Poster Reception: 5:00 – 6:30 p.m. Eastern Time
Location: Poster Hall, Thomas M. Menino Convention & Exhibition Center

Once the presentation has concluded, a copy of the materials will be added to the "Publications" section of the Company’s website at tscan.com.

(Press release, TScan Therapeutics, APR 27, 2026, View Source [SID1234664833])

Tessera Therapeutics to Present New Preclinical Data Supporting In Vivo Program in Sickle Cell Disease and Advancements in In Vivo CAR-T Applications at the American Society of Gene and Cell Therapy 29th Annual Meeting

On April 27, 2026 Tessera Therapeutics ("Tessera"), the biotechnology company pioneering a new approach in genetic medicine known as Gene Writing, reported four presentations of new preclinical data at the upcoming American Society of Gene and Cell Therapy (ASGCT) (Free ASGCT Whitepaper) Annual Meeting taking place in Boston, Massachusetts, May 11 – 15, 2026.

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Details of the Company’s ASGCT (Free ASGCT Whitepaper) 29th Annual Meeting presentations are as follows:

Oral presentations:

Title: Therapeutically relevant levels of in vivo HBB gene correction in Hematopoietic Stem Cells for the treatment of Sickle Cell Disease
Session: Advances in stem cell–directed gene therapy: Platforms, safety, and translation
Presenter: Giulia Schiroli, Ph.D.
Date and Time: May 12, 2026, 8:15 a.m. – 8:30 a.m. ET
Location: MCEC Room 206AB (Level 2)

Title: RNA Delivery by Targeted Lipid Nanoparticles Enable In Vivo Genome Editing of Hematopoietic Stem Cells and T Cells
Session: LNPs for in vivo CAR-T applications
Presenter: Mike Monte, Ph.D.
Date and Time: May 12, 2026, 8:30 a.m. – 8:45 a.m. ET
Location: MCEC Room 210ABC (Level 2)

Title: Targeted LNP Delivery of an RNA Gene Writer In Vivo Enables Generation of Functional CAR-T Cells in Animal Models
Session: In Vivo Engineering of CAR T-cells for Autoimmune Disease
Presenter: Alberto De Iaco, Ph.D.
Date and Time: May 14, 2026, 11:45 a.m. – 12:00 p.m. ET
Location: Westin Seaport Grand Ballroom CDE (Concourse Level)

Scientific Symposia:

Title: Characterization of LNP biophysical properties and impact on efficacy in vivo
Session: The biologic and biophysical challenges of LNP delivery: Opportunities to improve safety and efficacy
Presenter: Tom Colace, Ph.D.
Date and Time: May 15, 2026, 3:30 p.m. – 4:00 p.m. ET
Location: MCEC Room 107ABC (Level 1)

(Press release, Tessera Therapeutics, APR 27, 2026, View Source [SID1234664832])