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ICON Appoints New Chief Medical Officer

On May 5, 2020 ICON plc, (NASDAQ: ICLR) a leading global provider of drug and device development and commercialisation services to the pharmaceutical, biotechnology and medical device industries, reported that Dr. Kristen K. Buck has been appointed Chief Medical Officer (Press release, ICON, MAY 5, 2020, View Source [SID1234557050]).

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Kristen joins ICON from Optum Insights (part of the United Healthcare group) where she was SVP & Chief of Clinical Development. Kristen led the clinical operations and regulatory groups to create a Real-World Evidence and Outcomes clinical trial business. Her experience ranges over multiple therapy areas including GI, neuroscience, dermatology, ophthalmology, oncology, cardiovascular/metabolic, immunology, renal, women’s health, orphan diseases, liver, and psychiatry.

Kristen is a board certified and licenced physician from the Pennsylvania State University School of Medicine, and completed her Internship and Residency in Internal Medicine at Abington Memorial Hospital, before working as a primary care practitioner in a private practice. From there Kristen moved to the FDA in the GI and Hematology division, where she was responsible for reviewing efficacy and safety for all new indications, as well as post-marketing safety for over 40 drugs. Kristen spent time working at AstraZeneca in clinical development and in its Innovative Medicines group.

"We are delighted to appoint Dr Kristen Buck as our new Chief Medical Officer," said Steve Cutler, ICON’s Chief Executive Officer. "Kristen’s appointment will improve coordination and access to the significant medical and scientific resources and expertise we have at ICON. We will focus this expertise on helping our customers negotiate challenges, as we constantly strive to improve our services and respond to the latest issues and developments in science and medicine."

"I’m excited to be leading ICON’s position on clinical development trends, and reviewing and advising on our medical risks as the world wrestles with the Covid-19 pandemic," said Dr. Buck. "Patient centricity is ever more important in the current climate and I look forward to working with the wider ICON team to broaden our insights and expand our expertise."

Seattle Genetics to Present at the BofA Securities Virtual Health Care Conference 2020

On May 5, 2020 Seattle Genetics, Inc. (Nasdaq:SGEN) reported that management will participate in a fireside chat during the BofA Securities Virtual Health Care Conference 2020 on Tuesday, May 12, 2020 at 11:40 a.m. Eastern Time (Press release, Seattle Genetics, MAY 5, 2020, View Source [SID1234557049]). The presentation will be webcast live and available for replay from Seattle Genetics’ website at www.seattlegenetics.com in the Investors section.

OMEROS CORPORATION TO ANNOUNCE FIRST QUARTER FINANCIAL RESULTS ON MAY 11, 2020

On May 5, 2020 Omeros Corporation (NASDAQ: OMER), reported that the company will issue its first quarter financial results for the period ended March 31, 2020, on Monday, May 11, 2020, after the market closes (Press release, Omeros, MAY 5, 2020, View Source [SID1234557048]). Omeros management will host a conference call and webcast that day at 4:30 p.m. Eastern Time (1:30 p.m. Pacific Time) to discuss the financial results as well as recent developments and highlights.

Conference Call Details

To access the live conference call via phone, please dial (844) 831-4029 from the United States and Canada or (920) 663-6278 internationally. The participant passcode is 6549035. Please dial in approximately 10 minutes prior to the start of the call. A telephone replay will be available for one week following the call and may be accessed by dialing (855) 859-2056 from the United States and Canada or (404) 537-3406 internationally. The replay passcode is 6549035.

To access the live and subsequently archived webcast of the conference call, go to Omeros’ website at www.omeros.com and select "Events" under the Investors section of the website. Please connect to the website at least 15 minutes prior to the call to allow for any software download that may be necessary.

argenx to Present at BofA Securities Virtual Health Care Conference 2020

On May 5, 2020 argenx (Euronext & Nasdaq: ARGX), a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer, reported that Tim Van Hauwermeiren, Chief Executive Officer, will present at the BofA Securities Virtual Health Care Conference 2020 on Tuesday, May 12, 2020 at 1:00 p.m. ET (Press release, argenx, MAY 5, 2020, View Source [SID1234557047]).

A live webcast of the presentation will be available on the Investors section of the Company’s website at www.argenx.com. A replay of the webcast will be available for 90 days following the presentation.

Genprex Enters Into Exclusive Worldwide Patent and Technology License Agreement for Combination of its TUSC2 Gene Therapy with Immunotherapies

On May 5, 2020 Genprex, Inc. ("Genprex" or the "Company") (Nasdaq: GNPX), a clinical-stage gene therapy company developing potentially life-changing technologies for patients with cancer and diabetes, reported that it has entered into a Patent and Technology License Agreement ("License Agreement") with The University of Texas MD Anderson Cancer Center ("MD Anderson") in which MD Anderson granted to Genprex an exclusive worldwide license to a portfolio of 16 patent applications and related technology ("Licensed IP") for the treatment of cancer using Genprex’s lead drug candidate and TUSC2 gene therapy, known as "Oncoprex" or "GEN-001," in combination with immunotherapies (Press release, Genprex, MAY 5, 2020, View Source [SID1234557044]). This is a distinct therapeutic approach from that of combining Oncoprex with targeted therapies such as osimertinib (marketed as Tagrisso by AstraZeneca).

Genprex was recently awarded U.S. FDA Fast Track designation for use of Oncoprex combined with Tagrisso for the treatment of non-small cell lung cancer (NSCLC) patients with EGFR mutations whose tumors progressed after treatment with Tagrisso alone. The Company is now preparing to file an Investigational New Drug application to initiate a clinical trial of Oncoprex in combination with pembrolizumab (marketed as Keytruda by Merck) in NSCLC.

"We are pleased to advance the intellectual property that is covered by this License Agreement," said Rodney Varner, Genprex’s Chairman and Chief Executive Officer. "We are excited to be developing two distinct therapeutic approaches to lung cancer utilizing the combination of our gene therapy with successful targeted therapies, such as Tagrisso, and immunotherapies, such as Keytruda, to potentially improve patient outcomes and increase the number of patients who may benefit from these important therapies."

Immunotherapy or immunotherapy combined with chemotherapy is now the first-line standard of care for the majority of lung cancer patients. Published preclinical data indicate that when Oncoprex is combined with immunotherapies such as Keytruda, Oncoprex is synergistic with those drugs, meaning that the combination is more effective than either drug alone. The combination of Oncoprex and Keytruda may lead to better outcomes for many lung cancer patients.

The Licensed IP covers the use of Oncoprex in combination with one or more immunotherapies, including anti-PD1 antibodies, anti-PDL1 antibodies, anti-PDL2 antibodies, anti-CTLA-4 antibodies and/or anti-KIR antibodies for the treatment of cancer. These immunotherapies include pembrolizumab (Merck’s largest selling drug Keytruda), nivolumab (Bristol-Myers Squibb’s Opdivo), ipilimumab (Bristol-Myers Squibb’s Yervoy), and others. Use of chemotherapy in combination with Oncoprex and immunotherapy is also covered by the Licensed IP. While the initial disease indication for Oncoprex is NSCLC, the Licensed IP claims patent protection for combination use of Oncoprex in all types of cancers.

The License Agreement also provides for payment to MD Anderson of an up-front license fee and annual maintenance fees, with the potential for milestone payments, sublicensing fees, and product royalties.